U78 Benign neoplasm urinary tract (ICD-10:D30.9)

Introduction

Benign neoplasms of the urinary tract refer to non-cancerous growths that can occur in various parts of the urinary system, including the kidneys, bladder, ureters, and urethra^[1]. While these growths are typically not life-threatening, they can cause symptoms and complications that require medical attention^[2]. The aim of this guide is to provide healthcare professionals with a comprehensive overview of the diagnosis and management of benign neoplasms of the urinary tract.

Codes

• ICPC-2 Code: U78 Benign neoplasm urinary tract^[3]
• ICD-10 Code: D30.9 Benign neoplasm of urinary organ, unspecified^[4]

Symptoms

• Hematuria: Presence of blood in the urine^[5].
• Urinary frequency: Increased need to urinate^[6].
• Urinary urgency: Sudden and strong urge to urinate^[6].
• Dysuria: Pain or discomfort during urination^[7].
• Lower abdominal or pelvic pain: Dull or sharp pain in the lower abdomen or pelvic region^[8].
• Urinary tract infections: Recurrent or persistent urinary tract infections^[9].

Causes

• Genetic factors: Certain genetic mutations may increase the risk of developing benign neoplasms of the urinary tract^[10].
• Chronic inflammation: Conditions such as chronic urinary tract infections or kidney stones can lead to chronic inflammation, which may contribute to the development of benign neoplasms.
• Exposure to certain chemicals: Occupational exposure to certain chemicals, such as aromatic amines, may increase the risk of developing urinary tract neoplasms.

Diagnostic Steps

Medical History

• Gather information about the patient’s symptoms, including the duration, severity, and any associated factors.
• Inquire about the patient’s medical history, including any previous urinary tract infections, kidney stones, or other urinary tract conditions.
• Assess for any risk factors, such as occupational exposure to chemicals or a family history of urinary tract neoplasms.

Physical Examination

• Perform a thorough physical examination, including a pelvic examination in females, to assess for any palpable masses or abnormalities in the urinary tract.
• Check for any signs of infection, such as fever or tenderness in the lower abdomen.

Laboratory Tests

• Urinalysis: Evaluate the urine for the presence of blood, infection, or other abnormalities.
• Urine culture and sensitivity: Identify any bacterial infection and determine the appropriate antibiotic treatment.
• Complete blood count (CBC): Assess for any signs of infection or anemia.
• Renal function tests: Measure the levels of creatinine and blood urea nitrogen to assess kidney function.
• Tumor markers: In some cases, tumor markers such as urine cytology or urine-based molecular tests may be used to detect the presence of abnormal cells.

Diagnostic Imaging

• Ultrasound: Non-invasive imaging technique that can visualize the urinary tract and detect any abnormalities, such as tumors or cysts.
• CT scan: Provides detailed cross-sectional images of the urinary tract, allowing for a more accurate assessment of the size, location, and characteristics of any neoplasms.
• MRI: Useful for evaluating the extent of the neoplasm and its relationship to surrounding structures.
• Cystoscopy: Involves inserting a thin, flexible tube with a camera into the urethra and bladder to directly visualize the urinary tract and obtain biopsies if necessary.

Other Tests

• Biopsy: In cases where the diagnosis is uncertain or further characterization of the neoplasm is needed, a biopsy may be performed to obtain a tissue sample for pathological examination.
• Urodynamic studies: Assess the function of the urinary tract, including bladder capacity, pressure, and flow rates.

Follow-up and Patient Education

• Schedule regular follow-up appointments to monitor the progression of the neoplasm and assess for any changes in symptoms or complications.
• Provide education to the patient regarding the nature of the neoplasm, treatment options, and potential complications.
• Encourage the patient to report any new or worsening symptoms promptly.

Possible Interventions

Traditional Interventions

Medications:

Top 5 drugs for Benign neoplasm urinary tract:

1. Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., Ibuprofen, Naproxen):
   • Cost: Generic versions can be $3-$20/month.
   • Contraindications: History of gastrointestinal bleeding, renal impairment, or allergy to NSAIDs.
   • Side effects: Upset stomach, gastrointestinal bleeding, kidney problems.
   • Severe side effects: Severe allergic reactions, liver or kidney failure.
   • Drug interactions: Anticoagulants, corticosteroids, selective serotonin reuptake inhibitors (SSRIs).
   • Warning: Prolonged use may increase the risk of cardiovascular events.
2. Antibiotics (e.g., Ciprofloxacin, Trimethoprim/sulfamethoxazole):
   • Cost: Generic versions can be $3-$30/month.
   • Contraindications: Allergy to antibiotics, history of tendonitis or tendon rupture.
   • Side effects: Upset stomach, diarrhea, rash.
   • Severe side effects: Severe allergic reactions, tendonitis or tendon rupture.
   • Drug interactions: Antacids, warfarin, oral contraceptives.
   • Warning: Use with caution in patients with renal impairment.
3. Alpha-blockers (e.g., Tamsulosin, Alfuzosin):
   • Cost: Generic versions can be $10-$50/month.
   • Contraindications: Hypersensitivity to alpha-blockers, severe liver impairment.
   • Side effects: Dizziness, low blood pressure, retrograde ejaculation.
   • Severe side effects: Priapism (prolonged erection), angioedema.
   • Drug interactions: Other alpha-blockers, antihypertensive medications.
   • Warning: May cause dizziness or fainting, especially when standing up.
4. Hormonal therapy (e.g., Leuprolide, Goserelin):
   • Cost: Varies depending on the specific medication and dosage.
   • Contraindications: Hypersensitivity to hormonal therapy, pregnancy.
   • Side effects: Hot flashes, decreased libido, fatigue.
   • Severe side effects: Osteoporosis, mood changes, cardiovascular events.
   • Drug interactions: None specified.
   • Warning: May cause temporary worsening of symptoms before improvement.
5. Immunotherapy (e.g., Bacillus Calmette-Guérin (BCG)):
   • Cost: Varies depending on the specific medication and dosage.
   • Contraindications: Active infections, immunosuppression.
   • Side effects: Flu-like symptoms, urinary frequency, bladder irritation.
   • Severe side effects: Systemic infection, severe bladder irritation.
   • Drug interactions: None specified.
   • Warning: Requires close monitoring for potential complications.

Surgical Procedures:

• Transurethral resection of the bladder tumor (TURBT): Involves removing the tumor from the bladder using a specialized instrument inserted through the urethra. Cost: $10,000 to $30,000.
• Partial nephrectomy: Surgical removal of a portion of the kidney containing the neoplasm. Cost: $20,000 to $50,000.
• Ureteroscopic laser lithotripsy: Used to remove or fragment stones in the ureter or kidney using laser energy. Cost: $10,000 to $20,000.
• Radical cystectomy: Surgical removal of the entire bladder and nearby lymph nodes. Cost: $50,000 to $100,000.
• Nephroureterectomy: Surgical removal of the kidney and ureter affected by the neoplasm. Cost: $30,000 to $70,000.

Alternative Interventions

• Acupuncture: May help alleviate pain and improve overall well-being. Cost: $60-$120 per session.
• Herbal supplements: Some herbal supplements, such as green tea extract or turmeric, may have potential anti-inflammatory and antioxidant effects. Cost: Varies depending on the specific supplement.
• Mind-body techniques: Practices such as meditation, yoga, or tai chi may help reduce stress and improve overall health. Cost: Varies depending on the specific program or class.
• Dietary modifications: A diet rich in fruits, vegetables, and whole grains, and low in processed foods and red meat, may help support overall health and reduce inflammation. Cost: Varies depending on individual food choices.
• Physical therapy: Pelvic floor exercises or other targeted exercises may help improve urinary symptoms and pelvic muscle strength. Cost: Varies depending on the specific program or therapist.

Lifestyle Interventions

• Smoking cessation: Smoking has been linked to an increased risk of urinary tract neoplasms. Encourage the patient to quit smoking and provide resources for smoking cessation programs. Cost: Varies depending on the specific program or medication.
• Weight management: Maintaining a healthy weight through a balanced diet and regular exercise may help reduce the risk of urinary tract neoplasms. Cost: Varies depending on individual food choices and exercise preferences.
• Hydration: Adequate hydration can help flush out toxins and reduce the risk of urinary tract infections. Encourage the patient to drink plenty of water throughout the day. Cost: Minimal.
• Stress management: Chronic stress may contribute to inflammation and other health problems. Encourage the patient to engage in stress-reducing activities, such as meditation or relaxation techniques. Cost: Varies depending on the specific program or activity.
• Regular exercise: Engaging in regular physical activity can help maintain overall health and reduce the risk of chronic diseases. Encourage the patient to find activities they enjoy and can incorporate into their daily routine. Cost: Varies depending on individual preferences and access to exercise facilities.

It is important to note that the cost ranges provided are approximate and may vary depending on the location and availability of the interventions.

Mirari Cold Plasma Alternative Intervention

Understanding Mirari Cold Plasma

• Safe and Non-Invasive Treatment: Mirari Cold Plasma is a safe and non-invasive treatment option for various skin conditions. It does not require incisions, minimizing the risk of scarring, bleeding, or tissue damage.
• Efficient Extraction of Foreign Bodies: Mirari Cold Plasma facilitates the removal of foreign bodies from the skin by degrading and dissociating organic matter, allowing easier access and extraction.
• Pain Reduction and Comfort: Mirari Cold Plasma has a local analgesic effect, providing pain relief during the treatment, making it more comfortable for the patient.
• Reduced Risk of Infection: Mirari Cold Plasma has antimicrobial properties, effectively killing bacteria and reducing the risk of infection.
• Accelerated Healing and Minimal Scarring: Mirari Cold Plasma stimulates wound healing and tissue regeneration, reducing healing time and minimizing the formation of scars.

Mirari Cold Plasma Prescription

Video instructions for using Mirari Cold Plasma Device – U78 Benign neoplasm urinary tract (ICD-10:D30.9)

Localized (0) Sacrum (1) Prostate & Uterus (2) Kidney, Liver & Spleen (3) Heart, Bile & Pancreas (4) Lungs (5) Throat, Lymphatic & Thyroid (6) Neuro system & ENT (7)

Use the Mirari Cold Plasma device to treat Benign neoplasm urinary tract effectively.

WARNING: MIRARI COLD PLASMA IS DESIGNED FOR THE HUMAN BODY WITHOUT ANY ARTIFICIAL OR THIRD PARTY PRODUCTS. USE OF OTHER PRODUCTS IN COMBINATION WITH MIRARI COLD PLASMA MAY CAUSE UNPREDICTABLE EFFECTS, HARM OR INJURY. PLEASE CONSULT A MEDICAL PROFESSIONAL BEFORE COMBINING ANY OTHER PRODUCTS WITH USE OF MIRARI.

Step 1: Cleanse the Skin

• Start by cleaning the affected area of the skin with a gentle cleanser or mild soap and water. Gently pat the area dry with a clean towel.

Step 2: Prepare the Mirari Cold Plasma device

• Ensure that the Mirari Cold Plasma device is fully charged or has fresh batteries as per the manufacturer’s instructions. Make sure the device is clean and in good working condition.
• Switch on the Mirari device using the power button or by following the specific instructions provided with the device.
• Some Mirari devices may have adjustable settings for intensity or treatment duration. Follow the manufacturer’s instructions to select the appropriate settings based on your needs and the recommended guidelines.

Step 3: Apply the Device

• Place the Mirari device in direct contact with the affected area of the skin. Gently glide or hold the device over the skin surface, ensuring even coverage of the area experiencing.
• Slowly move the Mirari device in a circular motion or follow a specific pattern as indicated in the user manual. This helps ensure thorough treatment coverage.

Step 4: Monitor and Assess:

• Keep track of your progress and evaluate the effectiveness of the Mirari device in managing your Benign neoplasm urinary tract. If you have any concerns or notice any adverse reactions, consult with your health care professional.

Note

This guide is for informational purposes only and should not replace the advice of a medical professional. Always consult with your healthcare provider or a qualified medical professional for personal advice, diagnosis, or treatment. Do not solely rely on the information presented here for decisions about your health. Use of this information is at your own risk. The authors of this guide, nor any associated entities or platforms, are not responsible for any potential adverse effects or outcomes based on the content.

Mirari Cold Plasma System Disclaimer

• Purpose: The Mirari Cold Plasma System is a Class 2 medical device designed for use by trained healthcare professionals. It is registered for use in Thailand and Vietnam. It is not intended for use outside of these locations.
• Informational Use: The content and information provided with the device are for educational and informational purposes only. They are not a substitute for professional medical advice or care.
• Variable Outcomes: While the device is approved for specific uses, individual outcomes can differ. We do not assert or guarantee specific medical outcomes.
• Consultation: Prior to utilizing the device or making decisions based on its content, it is essential to consult with a Certified Mirari Tele-Therapist and your medical healthcare provider regarding specific protocols.
• Liability: By using this device, users are acknowledging and accepting all potential risks. Neither the manufacturer nor the distributor will be held accountable for any adverse reactions, injuries, or damages stemming from its use.
• Geographical Availability: This device has received approval for designated purposes by the Thai and Vietnam FDA. As of now, outside of Thailand and Vietnam, the Mirari Cold Plasma System is not available for purchase or use.

References

1. Yaxley JP. Urinary tract cancers: An overview for general practice. Aust Fam Physician. 2016;45(9):628-632.
2. Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE. The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours. Eur Urol. 2016;70(1):106-119.
3. ICPC-2 – English. https://www.gesy.org.cy/el-gr/annualreport/icpc-2-english1-10.pdf. Accessed June 28, 2024.
4. 2024 ICD-10-CM Diagnosis Code D30.9: Benign neoplasm of urinary organ, unspecified. https://www.icd10data.com/ICD10CM/Codes/C00-D49/D10-D36/D30-/D30.9. Accessed June 28, 2024.
5. Vinmec. Signs of urinary tract cancer. https://www.vinmec.com/oncology-radiotherapy/health-news/signs-of-urinary-tract-cancer/?link_type=related_posts. Accessed June 28, 2024.
6. Patient Power. Benign Bladder Tumors: Types, Symptoms and Treatment. https://www.patientpower.info/bladder-cancer/benign-bladder-tumor. Accessed June 28, 2024.
7. Cancer.ca. Non-cancerous tumours and conditions of the bladder. https://cancer.ca/en/cancer-information/cancer-types/bladder/what-is-bladder-cancer/non-cancerous-tumours. Accessed June 28, 2024.
8. Mayo Clinic. Bladder cancer – Symptoms and causes. https://www.mayoclinic.org/diseases-conditions/bladder-cancer/symptoms-causes/syc-20356104. Accessed June 28, 2024.
9. Healthline. Benign Bladder Tumor. https://www.healthline.com/health/benign-bladder-tumor. Accessed June 28, 2024.
10. Vinmec. The role of ultrasound in the diagnosis of bladder tumors. https://www.vinmec.com/en/news/health-news/general-health-check/the-role-of-ultrasound-in-the-diagnosis-of-bladder-tumors/. Accessed June 28, 2024.