U77 Malignant neoplasm urinary other (ICD-10:C68.9)

Introduction

Malignant neoplasm urinary other refers to the presence of cancerous cells in the urinary system that are not specific to the bladder, kidney, or prostate^[1]. This condition is significant as it can lead to various complications and requires prompt diagnosis and treatment^[2]. The aim of this guide is to provide healthcare professionals with a comprehensive overview of the diagnostic steps, possible interventions, and patient education for malignant neoplasm urinary other.

Codes

• ICPC-2 Code: U77 Malignant neoplasm urinary other
• ICD-10 Code: C68.9 Malignant neoplasm of urinary organ, unspecified

Symptoms

• Hematuria: Presence of blood in the urine^[3]
• Urinary frequency: Increased need to urinate^[4]
• Urinary urgency: Sudden and strong urge to urinate^[4]
• Dysuria: Pain or discomfort during urination^[5]
• Lower back pain: Pain in the lower back region^[6]
• Pelvic pain: Pain in the pelvic area^[6]
• Fatigue: Feeling tired or weak^[7]
• Unexplained weight loss: Losing weight without trying^[7]

Causes

• Smoking: Tobacco use increases the risk of developing urinary tract cancers^[8].
• Exposure to certain chemicals: Occupational exposure to chemicals such as aromatic amines and polycyclic aromatic hydrocarbons may increase the risk^[9].
• Chronic bladder inflammation: Conditions such as urinary tract infections or bladder stones can lead to chronic inflammation, increasing the risk of cancer.
• Family history: Having a family history of urinary tract cancers can increase the risk^[10].
• Age: The risk of developing urinary tract cancers increases with age.

Diagnostic Steps

Medical History

• Gather information about the patient’s risk factors, such as smoking history, occupational exposures, and family history of urinary tract cancers.
• Inquire about the presence of symptoms such as hematuria, urinary frequency, urgency, dysuria, lower back pain, pelvic pain, fatigue, and unexplained weight loss.
• Assess the patient’s medical history for conditions that may increase the risk of urinary tract cancers, such as chronic bladder inflammation or previous radiation therapy.

Physical Examination

• Perform a thorough physical examination, including a general examination of the patient’s overall health.
• Focus on specific signs or findings indicative of urinary tract cancers, such as palpable masses in the abdomen or pelvis, enlarged lymph nodes, or tenderness in the lower back or pelvic region.

Laboratory Tests

• Urinalysis: Analyze a urine sample for the presence of blood, abnormal cells, or other signs of urinary tract cancers.
• Complete blood count (CBC): Evaluate the levels of red and white blood cells, as well as platelets, which may be affected by urinary tract cancers.
• Kidney function tests: Measure the levels of creatinine and blood urea nitrogen (BUN) to assess kidney function.
• Liver function tests: Check liver enzymes and bilirubin levels to evaluate liver function, as urinary tract cancers can spread to the liver.

Diagnostic Imaging

• CT scan: Use computed tomography to visualize the urinary system and detect any abnormalities or tumors.
• MRI: Employ magnetic resonance imaging to obtain detailed images of the urinary system, providing further information about the location and extent of tumors.
• Ultrasound: Utilize ultrasound imaging to assess the kidneys, bladder, and other structures of the urinary system for any abnormalities or tumors.
• X-ray: Perform X-rays of the urinary system to identify any tumors or blockages.

Other Tests

• Cystoscopy: Insert a thin, flexible tube with a camera into the urethra and bladder to visualize the interior and identify any abnormalities or tumors.
• Biopsy: Collect a tissue sample from the urinary tract for laboratory analysis to confirm the presence of cancerous cells and determine the type and stage of the cancer.

Follow-up and Patient Education

• Schedule regular follow-up appointments to monitor the patient’s condition, response to treatment, and overall well-being.
• Provide patient education on the importance of adherence to treatment plans, lifestyle modifications, and regular screenings to detect any recurrence or new tumors.

Possible Interventions

Traditional Interventions

Medications:

Top 5 drugs for Malignant neoplasm urinary other:

1. Cisplatin:
   • Cost: $1000-$2000 per cycle.
   • Contraindications: Severe kidney impairment, hearing loss, and myelosuppression.
   • Side effects: Nausea, vomiting, kidney damage, and peripheral neuropathy.
   • Severe side effects: Bone marrow suppression, allergic reactions, and renal toxicity.
   • Drug interactions: Aminoglycoside antibiotics, NSAIDs, and nephrotoxic drugs.
   • Warning: Requires close monitoring of kidney function and hydration status.
2. Gemcitabine:
   • Cost: $1000-$2000 per cycle.
   • Contraindications: Severe kidney impairment and myelosuppression.
   • Side effects: Nausea, vomiting, flu-like symptoms, and myelosuppression.
   • Severe side effects: Bone marrow suppression, allergic reactions, and liver toxicity.
   • Drug interactions: Nephrotoxic drugs and drugs that affect liver function.
   • Warning: Requires close monitoring of kidney function and blood counts.
3. Methotrexate:
   • Cost: $100-$500 per cycle.
   • Contraindications: Severe liver or kidney impairment, pregnancy, and breastfeeding.
   • Side effects: Nausea, vomiting, mouth sores, and myelosuppression.
   • Severe side effects: Bone marrow suppression, liver toxicity, and lung inflammation.
   • Drug interactions: NSAIDs, penicillin, and drugs that affect liver or kidney function.
   • Warning: Requires close monitoring of liver function, kidney function, and blood counts.
4. Vinblastine:
   • Cost: $100-$500 per cycle.
   • Contraindications: Severe liver or kidney impairment, pregnancy, and breastfeeding.
   • Side effects: Nausea, vomiting, constipation, and myelosuppression.
   • Severe side effects: Bone marrow suppression, peripheral neuropathy, and allergic reactions.
   • Drug interactions: Drugs that affect liver or kidney function.
   • Warning: Requires close monitoring of liver function, kidney function, and blood counts.
5. Paclitaxel:
   • Cost: $1000-$2000 per cycle.
   • Contraindications: Severe liver or kidney impairment, pregnancy, and breastfeeding.
   • Side effects: Nausea, vomiting, hair loss, and myelosuppression.
   • Severe side effects: Bone marrow suppression, peripheral neuropathy, and allergic reactions.
   • Drug interactions: Drugs that affect liver or kidney function.
   • Warning: Requires close monitoring of liver function, kidney function, and blood counts.

Alternative Drugs:

• Carboplatin: A platinum-based chemotherapy drug that may be used as an alternative to cisplatin.
• Docetaxel: A taxane chemotherapy drug that may be used as an alternative to paclitaxel.
• Ifosfamide: A chemotherapy drug that may be used as an alternative to gemcitabine.
• Etoposide: A topoisomerase inhibitor chemotherapy drug that may be used as an alternative to vinblastine.
• Fluorouracil: A chemotherapy drug that may be used as an alternative to methotrexate.

Surgical Procedures:

• Radical cystectomy: Surgical removal of the bladder, nearby lymph nodes, and surrounding organs if necessary. Cost: $50,000-$100,000.
• Nephroureterectomy: Surgical removal of the kidney and ureter affected by the cancer. Cost: $30,000-$60,000.
• Partial nephrectomy: Surgical removal of the tumor and a portion of the kidney. Cost: $20,000-$40,000.
• Transurethral resection of bladder tumor (TURBT): Surgical removal of bladder tumors using a cystoscope. Cost: $10,000-$20,000.
• Lymph node dissection: Surgical removal of lymph nodes in the pelvic region to assess the spread of cancer. Cost: $10,000-$20,000.

Alternative Interventions

• Acupuncture: May help alleviate pain and improve overall well-being. Cost: $60-$120 per session.
• Herbal supplements: Some herbs, such as green tea extract and turmeric, have potential anti-cancer properties. Cost: Varies depending on the specific supplement.
• Mind-body techniques: Practices like meditation and yoga can help reduce stress and improve quality of life. Cost: Varies depending on the specific program or class.
• Dietary modifications: A diet rich in fruits, vegetables, and whole grains may have a positive impact on overall health. Cost: Varies depending on individual food choices.
• Exercise therapy: Regular physical activity can improve strength, endurance, and overall well-being. Cost: Varies depending on the specific program or gym membership.

Lifestyle Interventions

• Smoking cessation: Quitting smoking can significantly reduce the risk of developing urinary tract cancers. Cost: Varies depending on the chosen smoking cessation method.
• Healthy diet: Encourage a balanced diet rich in fruits, vegetables, whole grains, and lean proteins. Cost: Varies depending on individual food choices.
• Regular exercise: Promote regular physical activity, such as walking, swimming, or cycling. Cost: Varies depending on the chosen activity or gym membership.
• Stress management: Encourage stress-reducing techniques, such as meditation, deep breathing exercises, or engaging in hobbies. Cost: Varies depending on the chosen method or class.
• Regular screenings: Emphasize the importance of regular check-ups and screenings to detect any recurrence or new tumors. Cost: Varies depending on insurance coverage and healthcare provider.

It is important to note that the cost ranges provided are approximate and may vary depending on the location and availability of the interventions.

Mirari Cold Plasma Alternative Intervention

Understanding Mirari Cold Plasma

• Safe and Non-Invasive Treatment: Mirari Cold Plasma is a safe and non-invasive treatment option for various skin conditions. It does not require incisions, minimizing the risk of scarring, bleeding, or tissue damage.
• Efficient Extraction of Foreign Bodies: Mirari Cold Plasma facilitates the removal of foreign bodies from the skin by degrading and dissociating organic matter, allowing easier access and extraction.
• Pain Reduction and Comfort: Mirari Cold Plasma has a local analgesic effect, providing pain relief during the treatment, making it more comfortable for the patient.
• Reduced Risk of Infection: Mirari Cold Plasma has antimicrobial properties, effectively killing bacteria and reducing the risk of infection.
• Accelerated Healing and Minimal Scarring: Mirari Cold Plasma stimulates wound healing and tissue regeneration, reducing healing time and minimizing the formation of scars.

Mirari Cold Plasma Prescription

Video instructions for using Mirari Cold Plasma Device – U77 Malignant neoplasm urinary other (ICD-10:C68.9)

Localized (0) Sacrum (1) Prostate & Uterus (2) Kidney, Liver & Spleen (3) Heart, Bile & Pancreas (4) Lungs (5) Throat, Lymphatic & Thyroid (6) Neuro system & ENT (7)

Use the Mirari Cold Plasma device to treat Malignant neoplasm urinary other effectively.

WARNING: MIRARI COLD PLASMA IS DESIGNED FOR THE HUMAN BODY WITHOUT ANY ARTIFICIAL OR THIRD PARTY PRODUCTS. USE OF OTHER PRODUCTS IN COMBINATION WITH MIRARI COLD PLASMA MAY CAUSE UNPREDICTABLE EFFECTS, HARM OR INJURY. PLEASE CONSULT A MEDICAL PROFESSIONAL BEFORE COMBINING ANY OTHER PRODUCTS WITH USE OF MIRARI.

Step 1: Cleanse the Skin

• Start by cleaning the affected area of the skin with a gentle cleanser or mild soap and water. Gently pat the area dry with a clean towel.

Step 2: Prepare the Mirari Cold Plasma device

• Ensure that the Mirari Cold Plasma device is fully charged or has fresh batteries as per the manufacturer’s instructions. Make sure the device is clean and in good working condition.
• Switch on the Mirari device using the power button or by following the specific instructions provided with the device.
• Some Mirari devices may have adjustable settings for intensity or treatment duration. Follow the manufacturer’s instructions to select the appropriate settings based on your needs and the recommended guidelines.

Step 3: Apply the Device

• Place the Mirari device in direct contact with the affected area of the skin. Gently glide or hold the device over the skin surface, ensuring even coverage of the area experiencing.
• Slowly move the Mirari device in a circular motion or follow a specific pattern as indicated in the user manual. This helps ensure thorough treatment coverage.

Step 4: Monitor and Assess:

• Keep track of your progress and evaluate the effectiveness of the Mirari device in managing your Malignant neoplasm urinary other. If you have any concerns or notice any adverse reactions, consult with your health care professional.

Note

This guide is for informational purposes only and should not replace the advice of a medical professional. Always consult with your healthcare provider or a qualified medical professional for personal advice, diagnosis, or treatment. Do not solely rely on the information presented here for decisions about your health. Use of this information is at your own risk. The authors of this guide, nor any associated entities or platforms, are not responsible for any potential adverse effects or outcomes based on the content.

Mirari Cold Plasma System Disclaimer

• Purpose: The Mirari Cold Plasma System is a Class 2 medical device designed for use by trained healthcare professionals. It is registered for use in Thailand and Vietnam. It is not intended for use outside of these locations.
• Informational Use: The content and information provided with the device are for educational and informational purposes only. They are not a substitute for professional medical advice or care.
• Variable Outcomes: While the device is approved for specific uses, individual outcomes can differ. We do not assert or guarantee specific medical outcomes.
• Consultation: Prior to utilizing the device or making decisions based on its content, it is essential to consult with a Certified Mirari Tele-Therapist and your medical healthcare provider regarding specific protocols.
• Liability: By using this device, users are acknowledging and accepting all potential risks. Neither the manufacturer nor the distributor will be held accountable for any adverse reactions, injuries, or damages stemming from its use.
• Geographical Availability: This device has received approval for designated purposes by the Thai and Vietnam FDA. As of now, outside of Thailand and Vietnam, the Mirari Cold Plasma System is not available for purchase or use.

References

1. American Cancer Society. (2021). What Is Bladder Cancer? https://www.cancer.org/cancer/bladder-cancer/about/what-is-bladder-cancer.html
2. National Cancer Institute. (2021). Bladder Cancer Treatment (PDQ®)–Patient Version. https://www.cancer.gov/types/bladder/patient/bladder-treatment-pdq
3. American Cancer Society. (2021). Signs and Symptoms of Bladder Cancer. https://www.cancer.org/cancer/bladder-cancer/detection-diagnosis-staging/signs-and-symptoms.html
4. Mayo Clinic. (2021). Bladder cancer – Symptoms and causes. https://www.mayoclinic.org/diseases-conditions/bladder-cancer/symptoms-causes/syc-20356104
5. Cancer Research UK. (2021). Symptoms of bladder cancer. https://www.cancerresearchuk.org/about-cancer/bladder-cancer/symptoms
6. Urology Care Foundation. (2021). Bladder Cancer: Symptoms and Signs. https://www.urologyhealth.org/urology-a-z/b/bladder-cancer-symptoms-and-signs
7. American Cancer Society. (2021). Bladder Cancer Signs and Symptoms. https://www.cancer.org/cancer/bladder-cancer/detection-diagnosis-staging/signs-and-symptoms.html
8. American Cancer Society. (2021). Bladder Cancer Risk Factors. https://www.cancer.org/cancer/bladder-cancer/causes-risks-prevention/risk-factors.html
9. National Cancer Institute. (2021). Bladder Cancer Prevention (PDQ®)–Patient Version. https://www.cancer.gov/types/bladder/patient/bladder-prevention-pdq
10. Mayo Clinic. (2021). Bladder cancer – Causes. https://www.mayoclinic.org/diseases-conditions/bladder-cancer/symptoms-causes/syc-20356104