L99 Musculoskeletal disease, other (ICD-10:M99.9)

April 15, 2024

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Musculoskeletal diseases encompass a wide range of conditions that affect the muscles, bones, joints, and connective tissues. Musculoskeletal disease, other (ICPC-2: L99) refers to musculoskeletal conditions that do not fall into specific subcategories. This guide aims to provide an overview of the symptoms, causes, possible interventions, and patient education for musculoskeletal disease, other.


– ICPC-2 Code: L99 Musculoskeletal disease, other
– ICD-10 Code: M99.9 Biomechanical lesion, unspecified


  • Joint pain: Patients may experience pain in one or multiple joints.
  • Muscle weakness: Weakness or loss of strength in the muscles.
  • Limited range of motion: Difficulty moving a joint through its full range of motion.
  • Swelling: Swelling or inflammation in the affected area.
  • Stiffness: Stiffness in the joints, especially after periods of inactivity.
  • Fatigue: Generalized fatigue or tiredness.
  • Difficulty walking or performing daily activities: Impaired mobility and difficulty performing routine tasks.


  • Inflammatory conditions: Conditions such as rheumatoid arthritis, lupus, or gout can cause musculoskeletal symptoms.
  • Degenerative conditions: Conditions like osteoarthritis or degenerative disc disease can lead to musculoskeletal issues.
  • Trauma: Injuries, such as fractures or sprains, can result in musculoskeletal symptoms.
  • Infection: Certain infections, such as osteomyelitis or septic arthritis, can affect the musculoskeletal system.
  • Autoimmune disorders: Conditions like polymyalgia rheumatica or ankylosing spondylitis can cause musculoskeletal symptoms.
  • Genetic factors: Some musculoskeletal diseases have a genetic component.

Possible Interventions

Traditional Interventions


Top 5 drugs for Musculoskeletal disease, other:

  1. Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., Ibuprofen, Naproxen):
    • Cost: Generic versions can be $3-$20/month.
    • Contraindications: History of gastrointestinal bleeding, renal impairment, or allergy to NSAIDs.
    • Side effects: Upset stomach, heartburn, increased risk of bleeding.
    • Severe side effects: Gastrointestinal ulcers, kidney damage, cardiovascular events.
    • Drug interactions: Anticoagulants, corticosteroids, other NSAIDs.
    • Warning: Prolonged use may increase the risk of cardiovascular events.
  2. Corticosteroids (e.g., Prednisone, Dexamethasone):
    • Cost: Generic versions can be $4-$30/month.
    • Contraindications: Active infections, uncontrolled diabetes, systemic fungal infections.
    • Side effects: Increased appetite, weight gain, mood changes.
    • Severe side effects: Osteoporosis, adrenal suppression, increased susceptibility to infections.
    • Drug interactions: Nonsteroidal anti-inflammatory drugs, anticoagulants, certain anticonvulsants.
    • Warning: Long-term use may require gradual tapering to avoid adrenal insufficiency.
  3. Disease-modifying antirheumatic drugs (DMARDs) (e.g., Methotrexate, Sulfasalazine):
    • Cost: Generic versions can be $10-$100/month.
    • Contraindications: Pregnancy, liver disease, blood disorders.
    • Side effects: Nausea, fatigue, hair loss.
    • Severe side effects: Liver toxicity, bone marrow suppression, lung inflammation.
    • Drug interactions: NSAIDs, certain antibiotics, live vaccines.
    • Warning: Regular monitoring of liver function and blood counts is necessary.
  4. Muscle relaxants (e.g., Cyclobenzaprine, Methocarbamol):
    • Cost: Generic versions can be $4-$30/month.
    • Contraindications: Glaucoma, urinary retention, liver disease.
    • Side effects: Drowsiness, dizziness, dry mouth.
    • Severe side effects: Allergic reactions, liver toxicity.
    • Drug interactions: Sedatives, opioids, certain antidepressants.
    • Warning: May cause drowsiness, avoid driving or operating heavy machinery.
  5. Opioids (e.g., Oxycodone, Hydrocodone):
    • Cost: Generic versions can be $10-$100/month.
    • Contraindications: Respiratory depression, acute asthma, paralytic ileus.
    • Side effects: Constipation, drowsiness, nausea.
    • Severe side effects: Respiratory depression, addiction, overdose.
    • Drug interactions: Benzodiazepines, alcohol, certain antidepressants.
    • Warning: High potential for addiction and dependence, should be used cautiously and for short durations.

Alternative Drugs:

  • Antidepressants (e.g., Amitriptyline, Duloxetine): Can help manage chronic pain associated with musculoskeletal diseases.
  • Anticonvulsants (e.g., Gabapentin, Pregabalin): May be effective in reducing neuropathic pain.
  • Topical analgesics (e.g., Capsaicin cream, Lidocaine patches): Provide localized pain relief without systemic side effects.
  • Biologic agents (e.g., Adalimumab, Etanercept): Used for specific autoimmune conditions causing musculoskeletal symptoms.
  • Muscle relaxant injections (e.g., Botulinum toxin): Can be used for localized muscle spasm or pain relief.

Surgical Procedures:

  • Arthroscopy: Minimally invasive procedure to visualize and treat joint conditions. Cost: $5,000 to $10,000.
  • Joint replacement surgery: Involves replacing damaged joints with artificial implants. Cost: $20,000 to $50,000.
  • Spinal fusion: Joins two or more vertebrae to stabilize the spine. Cost: $50,000 to $100,000.
  • Tendon repair: Surgical repair of damaged tendons. Cost: $5,000 to $10,000.
  • Synovectomy: Removal of inflamed synovial tissue in joints. Cost: $5,000 to $10,000.

Alternative Interventions

  • Acupuncture: May help alleviate pain and improve musculoskeletal function. Cost: $60-$120 per session.
  • Chiropractic care: Manipulation of the spine and joints to relieve pain and improve mobility. Cost: $30-$200 per session.
  • Physical therapy: Exercises and techniques to improve strength, flexibility, and function. Cost: $50-$150 per session.
  • Massage therapy: Manual manipulation of soft tissues to reduce pain and promote relaxation. Cost: $50-$100 per session.
  • Yoga or Pilates: Gentle exercises that improve flexibility, strength, and posture. Cost: $10-$20 per class.

Lifestyle Interventions

  • Regular exercise: Engaging in low-impact exercises, such as swimming or walking, can help improve muscle strength and joint flexibility. Cost: Varies depending on the chosen activity.
  • Weight management: Maintaining a healthy weight can reduce stress on the joints and alleviate symptoms. Cost: Varies depending on dietary choices and potential need for professional guidance.
  • Heat or cold therapy: Applying heat or cold packs to the affected area can help reduce pain and inflammation. Cost: $10-$30 for reusable packs.
  • Assistive devices: Using braces, splints, or orthotics can provide support and relieve pressure on affected joints. Cost: Varies depending on the specific device.
  • Stress management techniques: Practicing relaxation techniques, such as meditation or deep breathing exercises, can help reduce muscle tension and improve overall well-being. Cost: Varies depending on chosen method.

It is important to note that the cost ranges provided are approximate and may vary depending on the location and availability of the interventions.

Mirari Cold Plasma Alternative Intervention

Understanding Mirari Cold Plasma

  • Safe and Non-Invasive Treatment: Mirari Cold Plasma is a safe and non-invasive treatment option for various skin conditions. It does not require incisions, minimizing the risk of scarring, bleeding, or tissue damage.
  • Efficient Extraction of Foreign Bodies: Mirari Cold Plasma facilitates the removal of foreign bodies from the skin by degrading and dissociating organic matter, allowing easier access and extraction.
  • Pain Reduction and Comfort: Mirari Cold Plasma has a local analgesic effect, providing pain relief during the treatment, making it more comfortable for the patient.
  • Reduced Risk of Infection: Mirari Cold Plasma has antimicrobial properties, effectively killing bacteria and reducing the risk of infection.
  • Accelerated Healing and Minimal Scarring: Mirari Cold Plasma stimulates wound healing and tissue regeneration, reducing healing time and minimizing the formation of scars.

Mirari Cold Plasma Prescription

Video instructions for using Mirari Cold Plasma Device – L99 Musculoskeletal disease, other (ICD-10:M99.9)

Mode setting: 2 (Wound Healing)
Location: 0 (Localized)
Morning: 15 minutes,
Evening: 15 minutes
Mode setting: 2 (Wound Healing)
Location: 0 (Localized)
Morning: 30 minutes,
Lunch: 30 minutes,
Evening: 30 minutes
Mode setting: 2 (Wound Healing)
Location: 0 (Localized)
Morning: 30 minutes,
Lunch: 30 minutes,
Evening: 30 minutes
Mode setting: 9 (Arthritis)
Location: 0 (Localized)
Morning: 15 minutes,
Evening: 15 minutes
Mode setting: 9 (Arthritis)
Location: 0 (Localized)
Morning: 30 minutes,
Lunch: 30 minutes,
Evening: 30 minutes
Mode setting: 9 (Arthritis)
Location: 0 (Localized)
Morning: 30 minutes,
Lunch: 30 minutes,
Evening: 30 minutes
Mode setting: 7 (Immunotherapy)
Location: 1 (Sacrum)
Morning: 15 minutes,
Evening: 15 minutes
Mode setting: 7 (Immunotherapy)
Location: 1 (Sacrum)
Morning: 30 minutes,
Lunch: 30 minutes,
Evening: 30 minutes
Mode setting: 7 (Immunotherapy)
Location: 1 (Sacrum)
Morning: 30 minutes,
Lunch: 30 minutes,
Evening: 30 minutes
Morning:ย 45ย minutesย approx.ย $7.50ย USD,
Evening:ย 45ย minutesย approx.ย $7.50ย USD
Morning:ย 90ย minutesย approx.ย $15ย USD,
Lunch:ย 90ย minutesย approx. $15 USD,
Evening:ย 90ย minutesย approx. $15 USD,
Morning:ย 90ย minutesย approx.ย $15ย USD,
Lunch:ย 90ย minutesย approx. $15 USD,
Evening:ย 90ย minutesย approx. $15 USD,
Usualย treatmentย forย 7-60ย daysย approx.ย $105ย USDย โ€“ย $900ย USDUsualย treatmentย forย 6-8ย weeksย approx.ย $1,890ย USDย โ€“ย $2,520ย USD
Usualย treatmentย forย 3-6ย monthsย approx.ย $4,050ย USDย โ€“ย $8,100ย USD
Location note miraridoctor 1
  • Localized (0)
  • Sacrum (1)
  • Prostate & Uterus (2)
  • Kidney, Liver & Spleen (3)
  • Heart, Bile & Pancreas (4)
  • Lungs (5)
  • Throat, Lymphatic & Thyroid (6)
  • Neuro system & ENT (7)

Use the Mirari Cold Plasma device to treat Musculoskeletal disease, other effectively.


Step 1: Cleanse the Skin

  • Start by cleaning the affected area of the skin with a gentle cleanser or mild soap and water. Gently pat the area dry with a clean towel.

Step 2: Prepare the Mirari Cold Plasma device

  • Ensure that the Mirari Cold Plasma device is fully charged or has fresh batteries as per the manufacturer’s instructions. Make sure the device is clean and in good working condition.
  • Switch on the Mirari device using the power button or by following the specific instructions provided with the device.
  • Some Mirari devices may have adjustable settings for intensity or treatment duration. Follow the manufacturer’s instructions to select the appropriate settings based on your needs and the recommended guidelines.

Step 3: Apply the Device

  • Place the Mirari device in direct contact with the affected area of the skin. Gently glide or hold the device over the skin surface, ensuring even coverage of the area experiencing.
  • Slowly move the Mirari device in a circular motion or follow a specific pattern as indicated in the user manual. This helps ensure thorough treatment coverage.

Step 4: Monitor and Assess:

  • Keep track of your progress and evaluate the effectiveness of the Mirari device in managing your Musculoskeletal disease, other. If you have any concerns or notice any adverse reactions, consult with your health care professional.


This guide is for informational purposes only and should not replace the advice of a medical professional. Always consult with your healthcare provider or a qualified medical professional for personal advice, diagnosis, or treatment. Do not solely rely on the information presented here for decisions about your health. Use of this information is at your own risk. The authors of this guide, nor any associated entities or platforms, are not responsible for any potential adverse effects or outcomes based on the content.

Mirari Cold Plasma System Disclaimer

  • Purpose: The Mirari Cold Plasma System is a Class 2 medical device designed for use by trained healthcare professionals. It is registered for use in Thailand and Vietnam. It is not intended for use outside of these locations.
  • Informational Use: The content and information provided with the device are for educational and informational purposes only. They are not a substitute for professional medical advice or care.
  • Variable Outcomes: While the device is approved for specific uses, individual outcomes can differ. We do not assert or guarantee specific medical outcomes.
  • Consultation: Prior to utilizing the device or making decisions based on its content, it is essential to consult with a Certified Mirari Tele-Therapist and your medical healthcare provider regarding specific protocols.
  • Liability: By using this device, users are acknowledging and accepting all potential risks. Neither the manufacturer nor the distributor will be held accountable for any adverse reactions, injuries, or damages stemming from its use.
  • Geographical Availability: This device has received approval for designated purposes by the Thai and Vietnam FDA. As of now, outside of Thailand and Vietnam, the Mirari Cold Plasma System is not available for purchase or use.
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