A99 General disease NOS (ICD-10:R69)

January 24, 2024

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General disease NOS (Not Otherwise Specified) refers to a condition where a patient presents with symptoms that do not fit into a specific disease category. This can make diagnosis and treatment challenging. The aim of this guide is to provide healthcare professionals with a comprehensive approach to diagnosing and managing patients with general disease NOS.


– ICPC-2 Code: A99 General disease NOS
– ICD-10 Code: R69 Unknown and unspecified causes of morbidity


  • Fatigue: Patients may experience persistent tiredness and lack of energy.
  • Pain: Patients may complain of generalized pain or discomfort.
  • Fever: Patients may have an elevated body temperature without an apparent cause.
  • Weight loss: Unexplained weight loss may be present.
  • Other non-specific symptoms: Patients may report symptoms such as headache, dizziness, or gastrointestinal disturbances.


  • Infection: General disease NOS can be caused by various infectious agents, including bacteria, viruses, and parasites.
  • Autoimmune disorders: Conditions such as systemic lupus erythematosus or rheumatoid arthritis can present with non-specific symptoms.
  • Metabolic disorders: Hormonal imbalances or metabolic abnormalities can lead to general disease NOS.
  • Environmental factors: Exposure to toxins or pollutants may contribute to the development of non-specific symptoms.
  • Psychological factors: Stress, anxiety, or depression can manifest as general disease NOS.

Diagnostic Steps

Medical History

  • Gather information about the patient’s symptoms, including their duration, severity, and any associated factors.
  • Identify any risk factors, such as recent travel, exposure to sick individuals, or occupational hazards.
  • Review the patient’s medical history, including any chronic conditions or previous diagnoses.
  • Assess the patient’s psychological well-being and inquire about any recent life events or stressors.

Physical Examination

  • Perform a thorough physical examination, including vital signs, general appearance, and specific organ system assessments.
  • Look for any signs of infection, inflammation, or abnormalities in the skin, lymph nodes, or other body systems.
  • Palpate for tenderness or swelling in specific areas of the body.
  • Evaluate the patient’s mental status and emotional well-being.

Laboratory Tests

  • Complete blood count (CBC): Assess for any abnormalities in red and white blood cell counts, as well as platelet levels.
  • Comprehensive metabolic panel (CMP): Evaluate organ function, electrolyte levels, and glucose levels.
  • Inflammatory markers: Measure levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) to assess for inflammation.
  • Infectious disease testing: Depending on the patient’s symptoms and risk factors, perform tests for specific infections, such as bacterial cultures, viral serologies, or parasite examinations.
  • Autoimmune markers: Test for specific autoantibodies, such as antinuclear antibodies (ANA) or rheumatoid factor (RF), to assess for autoimmune disorders.

Diagnostic Imaging

  • Chest X-ray: Evaluate the lungs and heart for any abnormalities.
  • Abdominal ultrasound: Assess the liver, gallbladder, kidneys, and other abdominal organs for any structural or functional abnormalities.
  • CT scan or MRI: Provide detailed imaging of specific body regions to identify any anatomical or pathological changes.
  • Bone scan: Assess for any bone abnormalities or metastatic lesions.
  • Other specialized imaging studies: Depending on the patient’s symptoms, perform additional imaging studies, such as a brain MRI or a PET scan.

Other Tests

  • Biopsy: If a specific organ or tissue is suspected to be involved, perform a biopsy to obtain a sample for further analysis.
  • Genetic testing: In certain cases, genetic testing may be warranted to identify any underlying genetic abnormalities.
  • Endoscopy: Use an endoscope to visualize and obtain samples from the gastrointestinal tract, respiratory system, or other body cavities.
  • Electrocardiogram (ECG): Evaluate the heart’s electrical activity and identify any abnormalities.
  • Pulmonary function tests: Assess lung function and identify any respiratory abnormalities.

Follow-up and Patient Education

  • Schedule follow-up appointments to monitor the patient’s progress and adjust the treatment plan as necessary.
  • Provide the patient with educational materials about their condition and the importance of adhering to the prescribed treatment.
  • Encourage the patient to maintain a healthy lifestyle, including regular exercise, a balanced diet, and stress management techniques.
  • Address any concerns or questions the patient may have and provide support throughout their healthcare journey.

Possible Interventions

Traditional Interventions


Top 5 drugs for General disease NOS:

  1. Analgesics (e.g., Acetaminophen, Ibuprofen):
    • Cost: Over-the-counter options are available at a low cost.
    • Contraindications: Allergy to the medication, severe liver or kidney disease.
    • Side effects: Upset stomach, allergic reactions.
    • Severe side effects: Liver or kidney damage.
    • Drug interactions: Other pain medications, blood thinners.
    • Warning: Do not exceed recommended dosage.
  2. Antibiotics (e.g., Amoxicillin, Azithromycin):
    • Cost: Generic versions can range from $4 to $30.
    • Contraindications: Allergy to the medication, certain medical conditions.
    • Side effects: Upset stomach, diarrhea.
    • Severe side effects: Severe allergic reactions, antibiotic resistance.
    • Drug interactions: Other medications that may interact with antibiotics.
    • Warning: Take the full course of antibiotics as prescribed.
  3. Antidepressants (e.g., Sertraline, Escitalopram):
    • Cost: Generic versions can range from $10 to $50.
    • Contraindications: Allergy to the medication, certain medical conditions.
    • Side effects: Nausea, drowsiness, sexual dysfunction.
    • Severe side effects: Suicidal thoughts, serotonin syndrome.
    • Drug interactions: Other medications that may interact with antidepressants.
    • Warning: May take several weeks to see the full effect.
  4. Antihistamines (e.g., Loratadine, Cetirizine):
    • Cost: Generic versions can range from $5 to $20.
    • Contraindications: Allergy to the medication, certain medical conditions.
    • Side effects: Drowsiness, dry mouth.
    • Severe side effects: Severe allergic reactions, difficulty breathing.
    • Drug interactions: Other medications that may interact with antihistamines.
    • Warning: Avoid driving or operating machinery if drowsiness occurs.
  5. Corticosteroids (e.g., Prednisone, Dexamethasone):
    • Cost: Generic versions can range from $4 to $30.
    • Contraindications: Allergy to the medication, certain medical conditions.
    • Side effects: Increased appetite, weight gain, mood changes.
    • Severe side effects: Increased risk of infections, osteoporosis.
    • Drug interactions: Other medications that may interact with corticosteroids.
    • Warning: Do not stop taking corticosteroids abruptly.

Alternative Drugs:

  • Antacids (e.g., Calcium carbonate): Used to relieve symptoms of indigestion or heartburn. Cost: $5-$15.
  • Antidiarrheals (e.g., Loperamide): Used to treat diarrhea. Cost: $5-$20.
  • Antiemetics (e.g., Ondansetron): Used to control nausea and vomiting. Cost: $10-$50.
  • Antispasmodics (e.g., Dicyclomine): Used to relieve muscle spasms. Cost: $10-$30.
  • Topical analgesics (e.g., Lidocaine patches): Used to provide localized pain relief. Cost: $10-$50.

Surgical Procedures:

  • Surgery may not be indicated for general disease NOS, as it is a non-specific condition. However, in cases where an underlying cause is identified, surgical intervention may be necessary. The cost of surgical procedures can vary significantly depending on the specific procedure and location.

Alternative Interventions

  • Acupuncture: May help alleviate pain and promote overall well-being. Cost: $60-$120 per session.
  • Chelation therapy: Controversial treatment involving the administration of chelating agents to remove heavy metals from the body. Cost: $75-$150 per session.
  • Herbal supplements: Some herbal supplements, such as turmeric or ginger, may have potential benefits for symptom relief. Cost: Varies depending on the specific supplement.
  • Mind-body techniques: Practices such as meditation, yoga, or tai chi can help reduce stress and improve overall health. Cost: Varies depending on the specific practice.
  • Massage therapy: Can help alleviate muscle tension and promote relaxation. Cost: $50-$100 per session.

Lifestyle Interventions

  • Regular exercise: Engaging in physical activity can improve overall health and reduce symptoms. Cost: Varies depending on the chosen activity (e.g., gym membership, equipment costs).
  • Healthy diet: Consuming a balanced diet rich in fruits, vegetables, whole grains, and lean proteins can support overall well-being. Cost: Varies depending on individual food choices.
  • Stress management techniques: Practicing stress reduction techniques such as deep breathing, meditation, or mindfulness can help improve symptoms. Cost: Varies depending on the chosen technique (e.g., free resources, paid classes).
  • Adequate sleep: Getting enough quality sleep can support overall health and improve symptoms. Cost: Varies depending on individual sleep needs and any necessary interventions (e.g., sleep aids).
  • Supportive therapies: Engaging in activities that bring joy and provide emotional support, such as spending time with loved ones or pursuing hobbies, can positively impact symptoms. Cost: Varies depending on individual preferences and chosen activities.

It is important to note that the cost ranges provided are approximate and may vary depending on the location and availability of the interventions. Additionally, it is crucial to consult with a healthcare professional before starting any new interventions or medications to ensure safety and appropriateness for individual patients.

Mirari Cold Plasma Alternative Intervention

Understanding Mirari Cold Plasma

  • Safe and Non-Invasive Treatment: Mirari Cold Plasma is a safe and non-invasive treatment option for various skin conditions. It does not require incisions, minimizing the risk of scarring, bleeding, or tissue damage.
  • Efficient Extraction of Foreign Bodies: Mirari Cold Plasma facilitates the removal of foreign bodies from the skin by degrading and dissociating organic matter, allowing easier access and extraction.
  • Pain Reduction and Comfort: Mirari Cold Plasma has a local analgesic effect, providing pain relief during the treatment, making it more comfortable for the patient.
  • Reduced Risk of Infection: Mirari Cold Plasma has antimicrobial properties, effectively killing bacteria and reducing the risk of infection.
  • Accelerated Healing and Minimal Scarring: Mirari Cold Plasma stimulates wound healing and tissue regeneration, reducing healing time and minimizing the formation of scars.

Mirari Cold Plasma Prescription

Video instructions for using Mirari Cold Plasma Device – A99 General disease NOS (ICD-10:R69)

Mode setting: 1 (Infection)
Location: 0 (Localized)
Morning: 15 minutes,
Evening: 15 minutes
Mode setting: 1 (Infection)
Location: 0 (Localized)
Morning: 30 minutes,
Lunch: 30 minutes,
Evening: 30 minutes
Mode setting: 1 (Infection)
Location: 0 (Localized)
Morning: 30 minutes,
Lunch: 30 minutes,
Evening: 30 minutes
Mode setting: 2 (Wound Healing)
Location: 0 (Localized)
Morning: 15 minutes,
Evening: 15 minutes
Mode setting: 2 (Wound Healing)
Location: 0 (Localized)
Morning: 30 minutes,
Lunch: 30 minutes,
Evening: 30 minutes
Mode setting: 2 (Wound Healing)
Location: 0 (Localized)
Morning: 30 minutes,
Lunch: 30 minutes,
Evening: 30 minutes
Morning:ย 30ย minutesย approx.ย $5ย USD,
Evening:ย 30ย minutesย approx.ย $5ย USD
Morning:ย 60ย minutesย approx.ย $10ย USD,
Lunch:ย 60ย minutesย approx.ย $10ย USD,
Evening:ย 60ย minutesย approx.ย $10ย USD
Morning:ย 60ย minutesย approx.ย $10ย USD,
Lunch:ย 60ย minutesย approx.ย $10ย USD,
Evening:ย 60ย minutesย approx.ย $10ย USD
Usualย treatmentย forย 7-60ย daysย approx.ย $70ย USDย โ€“ย $600ย USDUsualย treatmentย forย 6-8ย weeksย approx.ย $1,260ย USDย โ€“ย $1,680ย USD
Usualย treatmentย forย 3-6ย monthsย approx.ย $2,700ย USDย โ€“ย $5,400ย USD
Location note miraridoctor 1
  • Localized (0)
  • Sacrum (1)
  • Prostate & Uterus (2)
  • Kidney, Liver & Spleen (3)
  • Heart, Bile & Pancreas (4)
  • Lungs (5)
  • Throat, Lymphatic & Thyroid (6)
  • Neuro system & ENT (7)

Use the Mirari Cold Plasma device to treat General disease NOS effectively.


Step 1: Cleanse the Skin

  • Start by cleaning the affected area of the skin with a gentle cleanser or mild soap and water. Gently pat the area dry with a clean towel.

Step 2: Prepare the Mirari Cold Plasma device

  • Ensure that the Mirari Cold Plasma device is fully charged or has fresh batteries as per the manufacturer’s instructions. Make sure the device is clean and in good working condition.
  • Switch on the Mirari device using the power button or by following the specific instructions provided with the device.
  • Some Mirari devices may have adjustable settings for intensity or treatment duration. Follow the manufacturer’s instructions to select the appropriate settings based on your needs and the recommended guidelines.

Step 3: Apply the Device

  • Place the Mirari device in direct contact with the affected area of the skin. Gently glide or hold the device over the skin surface, ensuring even coverage of the area experiencing.
  • Slowly move the Mirari device in a circular motion or follow a specific pattern as indicated in the user manual. This helps ensure thorough treatment coverage.

Step 4: Monitor and Assess:

  • Keep track of your progress and evaluate the effectiveness of the Mirari device in managing your General disease NOS. If you have any concerns or notice any adverse reactions, consult with your health care professional.


This guide is for informational purposes only and should not replace the advice of a medical professional. Always consult with your healthcare provider or a qualified medical professional for personal advice, diagnosis, or treatment. Do not solely rely on the information presented here for decisions about your health. Use of this information is at your own risk. The authors of this guide, nor any associated entities or platforms, are not responsible for any potential adverse effects or outcomes based on the content.

Mirari Cold Plasma System Disclaimer

  • Purpose: The Mirari Cold Plasma System is a Class 2 medical device designed for use by trained healthcare professionals. It is registered for use in Thailand and Vietnam. It is not intended for use outside of these locations.
  • Informational Use: The content and information provided with the device are for educational and informational purposes only. They are not a substitute for professional medical advice or care.
  • Variable Outcomes: While the device is approved for specific uses, individual outcomes can differ. We do not assert or guarantee specific medical outcomes.
  • Consultation: Prior to utilizing the device or making decisions based on its content, it is essential to consult with a Certified Mirari Tele-Therapist and your medical healthcare provider regarding specific protocols.
  • Liability: By using this device, users are acknowledging and accepting all potential risks. Neither the manufacturer nor the distributor will be held accountable for any adverse reactions, injuries, or damages stemming from its use.
  • Geographical Availability: This device has received approval for designated purposes by the Thai and Vietnam FDA. As of now, outside of Thailand and Vietnam, the Mirari Cold Plasma System is not available for purchase or use.
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