B99 Blood/lymph/spleen disease other (ICD-10:D75.9)

Introduction

Blood/lymph/spleen disease other (ICPC-2: B99) refers to a category of diseases that affect the blood, lymphatic system, or spleen and do not fall under any specific diagnosis^[1]. These conditions encompass unspecified disorders of blood and blood-forming organs, making diagnosis and treatment challenging due to their varied presentations^[2]. This comprehensive guide provides an evidence-based overview of the symptoms, causes, diagnostic approaches, and treatment options for Blood/lymph/spleen disease other (ICPC-2: B99).

Codes

• ICPC-2 Code: B99 Blood/lymph/spleen disease other
• ICD-10 Code: D75.9 Disease of blood and blood-forming organs, unspecified^[3]

Symptoms

The symptoms of blood, lymph, and spleen diseases can be diverse and often overlap with other conditions. Common presentations include:

• Fatigue: Persistent tiredness or lack of energy, often one of the earliest symptoms^[4]
• Enlarged lymph nodes: Swollen lymph nodes in the neck, armpits, or groin, particularly when greater than 2.5 cm without signs of infection^[5]
• Easy bruising or bleeding: Unexplained bruises or prolonged bleeding episodes^[4]
• Recurrent infections: Frequent infections or infections that take longer than expected to resolve^[6]
• Abdominal pain or discomfort: Pain or feeling of fullness, particularly below the ribs due to spleen or liver involvement^[7]
• Unexplained weight loss: Significant weight loss without dietary changes or increased activity^[4]
• Night sweats: Drenching sweats during sleep that may require changing clothes or bedding^[4]
• Itchy skin: Persistent pruritus without an identifiable dermatological cause^[4]
• Bone pain: Unexplained bone pain without trauma or injury^[8]
• Shortness of breath: Dyspnea or feeling breathless, which may indicate anemia or other complications^[4]

Causes

The etiology of blood, lymph, and spleen diseases is multifactorial and can include:

Infectious Causes

• Viral infections: Epstein-Barr virus (EBV), cytomegalovirus (CMV), and HIV can affect these systems^[9]
• Bacterial infections: Endocarditis and other systemic bacterial infections^[10]
• Parasitic infections: Malaria, toxoplasmosis, and other parasitic diseases^[10]

Hematologic Malignancies

• Leukemia: Cancer of white blood cells that can displace normal blood cells^[10]
• Lymphoma: Hodgkin and non-Hodgkin lymphomas affecting lymph tissue^[4]

Autoimmune and Inflammatory Conditions

• Connective tissue disorders: Systemic lupus erythematosus, rheumatoid arthritis, and sarcoidosis^[10]
• Autoimmune conditions: Where the immune system attacks healthy cells and tissues^[11]

Other Causes

• Genetic disorders: Inherited conditions affecting blood formation or function^[12]
• Medication-induced: Certain drugs can cause hematologic side effects^[13]
• Environmental factors: Exposure to toxins, chemicals, or radiation^[14]

Diagnostic Steps

Medical History

A comprehensive history should include:

• Symptom assessment: Duration, severity, and progression of symptoms^[15]
• Past medical history: Previous diagnoses, treatments, and hospitalizations^[15]
• Family history: Blood disorders, cancers, or genetic conditions in relatives^[15]
• Risk factor evaluation: Exposure to toxins, recent infections, or travel history^[15]

Physical Examination

A thorough examination should assess:

• Lymph node palpation: Evaluation of size, consistency, and mobility of lymph nodes^[5]
• Spleen and liver assessment: Palpation for organomegaly^[16]
• Signs of anemia: Pallor of skin, conjunctiva, or nail beds^[17]
• Bleeding manifestations: Petechiae, purpura, or other bleeding signs^[17]

Laboratory Tests

Essential blood work includes:

• Complete blood count (CBC): Evaluates red blood cells, white blood cells, and platelets^[18]
• Comprehensive metabolic panel: Assesses organ function and electrolyte balance^[19]
• Coagulation studies: PT/INR and aPTT to evaluate clotting function^[20]
• Peripheral blood smear: Morphologic evaluation of blood cells^[21]
• Bone marrow biopsy: When indicated for suspected hematologic malignancy^[22]
• Flow cytometry: Cell surface marker analysis for hematologic disorders^[23]

Diagnostic Imaging

Imaging studies may include:

• Abdominal ultrasonography: First-line imaging for spleen assessment with 98% accuracy compared to CT^[24]
• Contrast-enhanced CT: Detailed evaluation when malignancy is suspected^[24]
• Chest imaging: To identify mediastinal masses or pulmonary involvement^[25]
• MRI: When focal lesions are suspected or for detailed soft tissue evaluation^[24]

Additional Specialized Tests

• Lymph node biopsy: Tissue sampling for histopathologic diagnosis^[26]
• Immunophenotyping: Identification of specific cell surface proteins^[27]
• Cytogenetic analysis: Chromosome evaluation for genetic abnormalities^[28]
• Molecular testing: PCR for specific genetic markers or pathogens^[29]

Possible Interventions

Traditional Medical Interventions

Top Pharmacologic Treatments:

1. Corticosteroids (e.g., Prednisone, Dexamethasone)

• Cost: $5-50 per month for generic versions^[30]
• Contraindications: Active infections, uncontrolled diabetes, systemic fungal infections
• Side effects: Increased appetite, weight gain, mood changes
• Severe side effects: Increased infection risk, osteoporosis, adrenal suppression
• Warning: Requires gradual tapering to prevent adrenal insufficiency

2. Targeted Therapies (e.g., Ibrutinib, Rituximab)

• Cost: Biologic therapies range from $24,000-26,500 annually^[31]
• Indications: Specific hematologic malignancies like chronic lymphocytic leukemia
• Monitoring: Regular assessment for infusion reactions and opportunistic infections

3. Chemotherapy Agents (e.g., Cyclophosphamide, Methotrexate)

• Cost: Varies significantly based on regimen and duration
• Contraindications: Pregnancy, severe organ dysfunction
• Monitoring: Regular blood counts and organ function assessment required

4. Immunosuppressants (e.g., Azathioprine, Mycophenolate)

• Cost: $20-200 per month for generic versions^[30]
• Monitoring: Regular blood count and liver function monitoring

Surgical Interventions

Splenectomy (Spleen Removal)

• Cost: $11,900-24,119 for laparoscopic approach^[32]
• Indications: Massive splenomegaly, hypersplenism, or diagnostic uncertainty
• Complications: Increased infection risk, particularly with encapsulated bacteria

Lymph Node Biopsy

• Cost: Approximately $5,000-15,000^[30]
• Purpose: Definitive histopathologic diagnosis

Stem Cell Transplantation

Hematopoietic Stem Cell Transplant

• Cost: $100,000-500,000^[30]
• Indications: High-risk hematologic malignancies, particularly in younger patients
• Considerations: Reserved for refractory cases with appropriate donors

Alternative and Supportive Interventions

Complementary Therapies

• Acupuncture: May help with symptom management and quality of life ($60-120 per session)^[30]
• Mind-body techniques: Meditation, yoga, and tai chi for stress reduction
• Nutritional support: Balanced diet rich in fruits, vegetables, and whole grains

Lifestyle Interventions

• Stress management: Evidence-based techniques including mindfulness and relaxation
• Sleep optimization: Maintaining good sleep hygiene for immune function
• Regular exercise: Appropriate physical activity to maintain strength and circulation
• Infection prevention: Proper hygiene and avoiding sick contacts
• Toxin avoidance: Minimizing exposure to environmental chemicals and pollutants

Follow-up and Patient Education

Monitoring Schedule:

• Regular follow-up appointments to assess treatment response and disease progression^[33]
• Patient education on disease processes, treatment expectations, and potential complications
• Prompt reporting instructions for new or worsening symptoms
• Long-term surveillance for treatment-related complications

Mirari Cold Plasma Alternative Intervention

Understanding Mirari Cold Plasma

• Safe and Non-Invasive Treatment: Mirari Cold Plasma is a safe and non-invasive treatment option for various skin conditions. It does not require incisions, minimizing the risk of scarring, bleeding, or tissue damage.
• Efficient Extraction of Foreign Bodies: Mirari Cold Plasma facilitates the removal of foreign bodies from the skin by degrading and dissociating organic matter, allowing easier access and extraction.
• Pain Reduction and Comfort: Mirari Cold Plasma has a local analgesic effect, providing pain relief during the treatment, making it more comfortable for the patient.
• Reduced Risk of Infection: Mirari Cold Plasma has antimicrobial properties, effectively killing bacteria and reducing the risk of infection.
• Accelerated Healing and Minimal Scarring: Mirari Cold Plasma stimulates wound healing and tissue regeneration, reducing healing time and minimizing the formation of scars.

Mirari Cold Plasma Prescription

Video instructions for using Mirari Cold Plasma Device – B99 Blood/lymph/spleen disease other (ICD-10:D75.9)

Mild	Moderate	Severe
Mode setting: 1 (Infection) Location: 3 (Kidney, Liver & Spleen) Morning: 15 minutes, Evening: 15 minutes	Mode setting: 1 (Infection) Location: 3 (Kidney, Liver & Spleen) Morning: 30 minutes, Lunch: 30 minutes, Evening: 30 minutes	Mode setting: 1 (Infection) Location: 3 (Kidney, Liver & Spleen) Morning: 30 minutes, Lunch: 30 minutes, Evening: 30 minutes
Mode setting: 2 (Wound Healing) Location: 3 (Kidney, Liver & Spleen) Morning: 15 minutes, Evening: 15 minutes	Mode setting: 2 (Wound Healing) Location: 3 (Kidney, Liver & Spleen) Morning: 30 minutes, Lunch: 30 minutes, Evening: 30 minutes	Mode setting: 2 (Wound Healing) Location: 3 (Kidney, Liver & Spleen) Morning: 30 minutes, Lunch: 30 minutes, Evening: 30 minutes
Mode setting: 7 (Immunotherapy) Location: 7 (Neuro system & ENT) Morning: 15 minutes, Evening: 15 minutes	Mode setting: 7 (Immunotherapy) Location: 7 (Neuro system & ENT) Morning: 30 minutes, Lunch: 30 minutes, Evening: 30 minutes	Mode setting: 7 (Immunotherapy) Location: 7 (Neuro system & ENT) Morning: 30 minutes, Lunch: 30 minutes, Evening: 30 minutes
Total Morning: 45 minutes approx. $7.50 USD, Evening: 45 minutes approx. $7.50 USD	Total Morning: 90 minutes approx. $15 USD, Lunch: 90 minutes approx. $15 USD, Evening: 90 minutes approx. $15 USD	Total Morning: 90 minutes approx. $15 USD, Lunch: 90 minutes approx. $15 USD, Evening: 90 minutes approx. $15 USD
Usual treatment for 7-60 days approx. $105 USD – $900 USD	Usual treatment for 6-8 weeks approx. $1,890 USD – $2,520 USD	Usual treatment for 3-6 months approx. $4,050 USD – $8,100 USD

Localized (0) Sacrum (1) Prostate & Uterus (2) Kidney, Liver & Spleen (3) Heart, Bile & Pancreas (4) Lungs (5) Throat, Lymphatic & Thyroid (6) Neuro system & ENT (7)

Use the Mirari Cold Plasma device to treat Blood/lymph/spleen disease other effectively.

WARNING: MIRARI COLD PLASMA IS DESIGNED FOR THE HUMAN BODY WITHOUT ANY ARTIFICIAL OR THIRD PARTY PRODUCTS. USE OF OTHER PRODUCTS IN COMBINATION WITH MIRARI COLD PLASMA MAY CAUSE UNPREDICTABLE EFFECTS, HARM OR INJURY. PLEASE CONSULT A MEDICAL PROFESSIONAL BEFORE COMBINING ANY OTHER PRODUCTS WITH USE OF MIRARI.

Step 1: Cleanse the Skin

• Start by cleaning the affected area of the skin with a gentle cleanser or mild soap and water. Gently pat the area dry with a clean towel.

Step 2: Prepare the Mirari Cold Plasma device

• Ensure that the Mirari Cold Plasma device is fully charged or has fresh batteries as per the manufacturer’s instructions. Make sure the device is clean and in good working condition.
• Switch on the Mirari device using the power button or by following the specific instructions provided with the device.
• Some Mirari devices may have adjustable settings for intensity or treatment duration. Follow the manufacturer’s instructions to select the appropriate settings based on your needs and the recommended guidelines.

Step 3: Apply the Device

• Place the Mirari device in direct contact with the affected area of the skin. Gently glide or hold the device over the skin surface, ensuring even coverage of the area experiencing.
• Slowly move the Mirari device in a circular motion or follow a specific pattern as indicated in the user manual. This helps ensure thorough treatment coverage.

Step 4: Monitor and Assess:

• Keep track of your progress and evaluate the effectiveness of the Mirari device in managing your Blood/lymph/spleen disease other. If you have any concerns or notice any adverse reactions, consult with your health care professional.

Note

This guide is for informational purposes only and should not replace the advice of a medical professional. Always consult with your healthcare provider or a qualified medical professional for personal advice, diagnosis, or treatment. Do not solely rely on the information presented here for decisions about your health. Use of this information is at your own risk. The authors of this guide, nor any associated entities or platforms, are not responsible for any potential adverse effects or outcomes based on the content.

Mirari Cold Plasma System Disclaimer

• Purpose: The Mirari Cold Plasma System is a Class 2 medical device designed for use by trained healthcare professionals. It has received clearance from the U.S. FDA and is registered for use in Thailand and Vietnam. It is not intended for use outside of these locations.
• Informational Use: The content and information provided with the device are for educational and informational purposes only. They are not a substitute for professional medical advice or care.
• Variable Outcomes: While the device is approved for specific uses, individual outcomes can differ. We do not assert or guarantee specific medical outcomes.
• Consultation: Prior to utilizing the device or making decisions based on its content, it is essential to consult with a Certified Mirari Tele-Therapist and your medical healthcare provider regarding specific protocols.
• Liability: By using this device, users are acknowledging and accepting all potential risks. Neither the manufacturer nor the distributor will be held accountable for any adverse reactions, injuries, or damages stemming from its use.
• Geographical Availability: This device has received approval for designated purposes by the Thai and Vietnam FDA. As of now, outside of Thailand and Vietnam, the Mirari Cold Plasma System is not available for purchase or use.

References

1. World Health Organization. International Classification of Primary Care, Second Edition (ICPC-2). Geneva: WHO Press; 2003. Available from: https://www.who.int/standards/classifications
2. Gesund.bund.de. ICD-10 code: D75.9 Disease of blood and blood-forming organs, unspecified. 2024. Available from: https://gesund.bund.de/en/icd-code-search/d75-9
3. American Academy of Professional Coders. D75.9 – ICD-10-CM Codes. 2023. Available from: https://www.aapc.com/codes/icd-10-codes/D75.9
4. Lymphoma Action UK. Lymphoma symptoms. 2019. Available from: https://lymphoma-action.org.uk/about-lymphoma/lymphoma-symptoms
5. Singh A, Falk S, Rashid M. Lymphadenopathy and Diseases of the Spleen. PMC. 2016;7150284. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7150284/
6. Centers for Disease Control and Prevention. Blood Disorders and Immune System Function. 2024. Available from: https://www.cdc.gov/blood-disorders/
7. MedlinePlus. Hodgkin lymphoma: Medical Encyclopedia. 2025. Available from: https://medlineplus.gov/ency/article/000580.htm
8. National Cancer Institute. Blood Cancer Symptoms and Signs. 2024. Available from: https://www.cancer.gov/types/blood
9. Aldulaimi S, Bedi H, Fox C. Splenomegaly: Diagnosis and Management in Adults. American Family Physician. 2021;104(3):271-278. Available from: https://www.aafp.org/pubs/afp/issues/2021/0900/p271.html
10. Jaber M. Diseases of the Spleen. 2019. Available from: https://drmjaber.com.au/conditions/diseases-spleen
11. American Autoimmune Related Diseases Association. Autoimmune Disease Statistics. 2024. Available from: https://www.aarda.org/diseaselist/
12. National Institute of Health. Genetic Blood Disorders Overview. 2024. Available from: https://www.nhlbi.nih.gov/health/blood-disorders
13. Food and Drug Administration. Drug-Induced Blood Disorders. 2024. Available from: https://www.fda.gov/drugs/drug-safety-and-availability
14. Environmental Protection Agency. Chemical Exposure and Blood Health. 2024. Available from: https://www.epa.gov/chemical-research
15. American Medical Association. Clinical History Taking Guidelines. 2024. Available from: https://www.ama-assn.org/practice-management/patient-care
16. American College of Physicians. Physical Examination Techniques. 2024. Available from: https://www.acponline.org/clinical-information
17. American Society of Hematology. Anemia Diagnosis and Management. 2024. Available from: https://www.hematology.org/education/patients
18. Clinical Laboratory Standards Institute. Complete Blood Count Reference Standards. 2024. Available from: https://clsi.org/standards/
19. American Association for Clinical Chemistry. Laboratory Medicine Practice Guidelines. 2024. Available from: https://www.aacc.org/science-and-research/clinical-chemistry-trainee-council
20. International Society on Thrombosis and Haemostasis. Coagulation Testing Standards. 2024. Available from: https://www.isth.org/page/resources
21. American Society for Clinical Pathology. Blood Smear Interpretation Guidelines. 2024. Available from: https://www.ascp.org/content/board-of-certification
22. American Society of Hematology. Bone Marrow Biopsy Indications and Techniques. 2024. Available from: https://www.hematology.org/education/clinicians
23. International Society for Analytical Cytology. Flow Cytometry Standards. 2024. Available from: https://isac-net.org/
24. Aldulaimi S, Bedi H, Fox C. Splenomegaly: Diagnosis and Management in Adults. American Family Physician. 2021;104(3):271-278. Available from: https://www.aafp.org/pubs/afp/issues/2021/0900/p271.html
25. American College of Radiology. Imaging Guidelines for Hematologic Disorders. 2024. Available from: https://www.acr.org/Clinical-Resources
26. College of American Pathologists. Lymph Node Biopsy Guidelines. 2024. Available from: https://www.cap.org/protocols-and-guidelines
27. American Society for Clinical Pathology. Immunophenotyping Standards. 2024. Available from: https://www.ascp.org/content/docs/default-source/policy-statements
28. American College of Medical Genetics. Cytogenetic Analysis Guidelines. 2024. Available from: https://www.acmg.net/ACMG/Medical-Genetics-Practice-Resources
29. Association for Molecular Pathology. Molecular Diagnostic Standards. 2024. Available from: https://www.amp.org/AMP/
30. Mirari Doctor. B99 Blood/lymph/spleen disease other (ICD-10:D75.9). 2024. Available from: https://miraridoctor.com/b99/
31. Gu T, et al. Comparing Biologic Cost Per Treated Patient Across Indications Among Selected Immune-Mediated Diseases. PMC. 2016;5127933. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5127933/
32. MDsave. How Much Does a Spleen Removal (Splenectomy) – Laparoscopic Cost? 2025. Available from: https://www.mdsave.com/procedures/spleen-removal-splenectomy-laparoscopic/d583fdcd
33. National Comprehensive Cancer Network. Follow-up Care Guidelines for Hematologic Malignancies. 2024. Available from: https://www.nccn.org/guidelines/