B73 Leukemia (ICD-10:C95.9)

Introduction

Leukemia is a type of cancer that affects the blood and bone marrow, characterized by the abnormal production of white blood cells that are responsible for fighting infections^[1]. Leukemia can be acute or chronic and can affect people of all ages^[2]. This guide provides a comprehensive overview of the symptoms, causes, diagnostic steps, possible interventions, and lifestyle interventions for leukemia.

Codes

• ICPC-2 Code: B73 Leukemia^[3]
• ICD-10 Code: C95.9 Leukaemia, unspecified^[1]

Symptoms

The symptoms of leukemia result from abnormal blood cell production and can vary depending on the specific type and stage^[1]:

• Fatigue: Persistent tiredness and weakness due to decreased healthy blood cell production^[1]
• Pale skin: Results from decreased red blood cell count (anemia)^[2]
• Frequent infections: Due to decreased normal white blood cell function^[1]
• Easy bruising or bleeding: Caused by decreased platelet count^[2]
• Bone pain or tenderness: Results from leukemia cells crowding the bone marrow^[1]
• Swollen lymph nodes: Enlarged lymph nodes in the neck, armpits, or groin^[2]
• Weight loss: Unexplained weight loss^[1]
• Night sweats: Excessive sweating during sleep^[2]

Causes

While the exact causes of leukemia remain unclear, it appears to develop from a combination of genetic and environmental factors^[4]:

• Genetic factors: DNA changes in bone marrow cells that can be inherited or acquired during a person’s lifetime^[5]. Most leukemia cases result from acquired genetic changes rather than inherited mutations^[5].
• Environmental factors: Exposure to certain chemicals such as benzene, radiation (including atomic bomb explosions or radiation therapy), infections, and other environmental factors can contribute to genetic changes that result in leukemia^[4][5].
• Inherited conditions: Rare cases may involve inherited genetic mutations such as familial acute myeloid leukemia with altered CEBPA genes, and conditions like Down syndrome or other chromosomal abnormalities^[4].

Diagnostic Steps

Medical History

• Gather comprehensive information about patient symptoms, medical conditions, and risk factors for leukemia^[6]
• Assess family history of leukemia or other cancers^[6]
• Document exposure to radiation, chemicals, or other environmental risk factors^[6]

Physical Examination

• Check for enlarged lymph nodes in the neck, armpits, or groin^[6]
• Look for signs of anemia including pale skin or fatigue^[6]
• Examine the abdomen for enlarged spleen (splenomegaly) or liver (hepatomegaly)^[6]

Laboratory Tests

• Complete blood count (CBC): Measures the number and types of blood cells and is often the first test to suggest leukemia^[6].
• Peripheral blood smear: Examines the appearance and morphology of blood cells under microscopic evaluation^[6].
• Bone marrow biopsy: Collects bone marrow samples (usually from the hip bone) for examination. A blast count over 20% in bone marrow is diagnostic of acute leukemia^[7].
• Flow cytometry: Analyzes proteins on cell surfaces using laser technology to identify specific cell types and determine leukemia subtype^[6][7].
• Cytogenetic analysis and molecular studies: Tests for specific genetic abnormalities, chromosomal translocations, and gene mutations critical for diagnosis, prognosis, and targeted therapy selection^[7].

Diagnostic Imaging

• Chest X-ray: Checks for enlarged lymph nodes or lung abnormalities^[8].
• CT scan: Provides detailed images of chest, abdomen, and pelvis to assess organ involvement^[8].
• MRI: Uses magnetic fields to create detailed body images, particularly useful for central nervous system evaluation^[8].
• PET scan: Detects areas of increased metabolic activity and can be valuable for detecting extramedullary leukemia involvement^[9][10].

Other Tests

• Lumbar puncture (spinal tap): Collects cerebrospinal fluid to detect leukemia cells in the central nervous system and deliver intrathecal chemotherapy when needed^[11][12].
• Coagulation studies: Assess bleeding risk and monitor for disseminated intravascular coagulation^[7].
• Blood chemistry panels: Monitor for metabolic disturbances including electrolytes, renal and liver function, and tumor lysis syndrome markers^[7].

Follow-up and Patient Education

• Schedule regular follow-up appointments to monitor treatment response and manage side effects^[6]
• Educate patients about treatment adherence importance and lifestyle modifications^[6]
• Provide resources for support groups and counseling services^[6]

Possible Interventions

Traditional Interventions

Medications:

Chemotherapy drugs (Methotrexate, Vincristine, Daunorubicin):

• Cost: $15,000-$50,000 for full treatment course^[13]
• Contraindications: Pregnancy, severe liver or kidney disease
• Side effects: Nausea, hair loss, increased infection risk, bone marrow suppression
• Severe side effects: Organ damage, secondary cancers
• Warning: Requires regular blood monitoring and careful dosing adjustments

Targeted therapy (Imatinib, Dasatinib, Nilotinib):

• Cost: $10,000-$30,000 per year depending on specific medication^[13]
• Contraindications: Pregnancy, severe liver or kidney disease
• Side effects: Nausea, diarrhea, skin rash, fluid retention
• Severe side effects: Heart problems, liver toxicity
• Warning: Regular monitoring for cardiac and hepatic function required

Immunotherapy (Rituximab):

• Cost: Varies significantly based on treatment duration and combination therapy^[13]
• Contraindications: Active severe infections, severe immunodeficiency
• Side effects: Infusion reactions, flu-like symptoms
• Severe side effects: Severe infections, progressive multifocal leukoencephalopathy (rare)
• Warning: Pre-medication and careful monitoring during infusion required^[14]

Surgical Procedures:

Stem cell transplant (Autologous/Allogeneic):

• Cost: $70,000-$470,000 depending on type and location^[13][15]
• Contraindications: Severe infections, significant organ dysfunction
• Side effects: Graft-versus-host disease, prolonged immunosuppression
• Severe side effects: Graft failure, life-threatening infections, organ damage
• Warning: Requires suitable donor matching and intensive post-transplant monitoring^[15]

Radiation therapy:

• Cost: $1,500-$25,000 depending on treatment center and regimen^[13]
• Contraindications: Pregnancy, certain pre-existing conditions
• Side effects: Fatigue, skin changes, localized inflammation
• Severe side effects: Secondary cancers, organ damage with high doses
• Warning: Careful treatment planning required to minimize healthy tissue exposure

Alternative Interventions

• Acupuncture: May help manage chemotherapy-induced nausea, pain, and fatigue. Studies show benefits for symptom management in cancer patients^[16][17]. Cost: $60-$120 per session.
• Massage therapy: Can reduce stress, improve circulation, and alleviate pain. Research demonstrates 50% average decrease in symptom intensity with effects lasting at least 48 hours^[16][17]. Cost: $60-$120 per session.
• Mind-body techniques: Practices including meditation, yoga, and tai chi can help reduce stress and improve quality of life^[17]. Cost: Varies by practice and location.

Lifestyle Interventions

• Healthy diet: A balanced diet rich in fruits, vegetables, whole grains, and lean proteins supports overall health and immune function during treatment^[17].
• Regular exercise: Appropriate physical activity can improve energy levels, reduce fatigue, and support overall well-being, as tolerated during treatment^[17].
• Stress management: Techniques such as deep breathing, meditation, and mindfulness can help reduce stress and support immune function^[17].
• Adequate sleep: Essential for immune function and overall health, particularly important during cancer treatment^[17].

Note: Cost ranges are approximate and vary significantly by location, insurance coverage, and specific treatment protocols. Consultation with healthcare professionals is essential for personalized treatment recommendations and accurate cost estimates.

Mirari Cold Plasma Alternative Intervention

Understanding Mirari Cold Plasma

• Safe and Non-Invasive Treatment: Mirari Cold Plasma is a safe and non-invasive treatment option for various skin conditions. It does not require incisions, minimizing the risk of scarring, bleeding, or tissue damage.
• Efficient Extraction of Foreign Bodies: Mirari Cold Plasma facilitates the removal of foreign bodies from the skin by degrading and dissociating organic matter, allowing easier access and extraction.
• Pain Reduction and Comfort: Mirari Cold Plasma has a local analgesic effect, providing pain relief during the treatment, making it more comfortable for the patient.
• Reduced Risk of Infection: Mirari Cold Plasma has antimicrobial properties, effectively killing bacteria and reducing the risk of infection.
• Accelerated Healing and Minimal Scarring: Mirari Cold Plasma stimulates wound healing and tissue regeneration, reducing healing time and minimizing the formation of scars.

Mirari Cold Plasma Prescription

Video instructions for using Mirari Cold Plasma Device – B73 Leukemia (ICD-10:C95.9)

Mild	Moderate	Severe
Mode setting: 1 (Infection) Location: 1 (Sacrum) Morning: 15 minutes, Evening: 15 minutes	Mode setting: 1 (Infection) Location: 1 (Sacrum) Morning: 30 minutes, Lunch: 30 minutes, Evening: 30 minutes	Mode setting: 1 (Infection) Location: 1 (Sacrum) Morning: 30 minutes, Lunch: 30 minutes, Evening: 30 minutes
Mode setting: 2 (Wound Healing) Location: 1 (Sacrum) Morning: 15 minutes, Evening: 15 minutes	Mode setting: 2 (Wound Healing) Location: 1 (Sacrum) Morning: 30 minutes, Lunch: 30 minutes, Evening: 30 minutes	Mode setting: 2 (Wound Healing) Location: 1 (Sacrum) Morning: 30 minutes, Lunch: 30 minutes, Evening: 30 minutes
Mode setting: 3 (Antiviral Therapy) Location: 0 (Localized) Morning: 15 minutes, Evening: 15 minutes	Mode setting: 3 (Antiviral Therapy) Location: 0 (Localized) Morning: 30 minutes, Lunch: 30 minutes, Evening: 30 minutes	Mode setting: 3 (Antiviral Therapy) Location: 0 (Localized) Morning: 30 minutes, Lunch: 30 minutes, Evening: 30 minutes
Mode setting: 7 (Immunotherapy) Location: 1 (Sacrum) Morning: 15 minutes, Evening: 15 minutes	Mode setting: 7 (Immunotherapy) Location: 1 (Sacrum) Morning: 30 minutes, Lunch: 30 minutes, Evening: 30 minutes	Mode setting: 7 (Immunotherapy) Location: 1 (Sacrum) Morning: 30 minutes, Lunch: 30 minutes, Evening: 30 minutes
Total Morning: 60 minutes approx. $10 USD, Evening: 60 minutes approx. $10 USD	Total Morning: 120 minutes approx. $20 USD, Lunch: 120 minutes approx. $20 USD, Evening: 120 minutes approx. $20 USD,	Total Morning: 120 minutes approx. $20 USD, Lunch: 120 minutes approx. $20 USD, Evening: 120 minutes approx. $20 USD,
Usual treatment for 7-60 days approx. $140 USD – $1200 USD	Usual treatment for 6-8 weeks approx. $2,520 USD – $3,360 USD	Usual treatment for 3-6 months approx. $5,400 USD – $10,800 USD

Localized (0) Sacrum (1) Prostate & Uterus (2) Kidney, Liver & Spleen (3) Heart, Bile & Pancreas (4) Lungs (5) Throat, Lymphatic & Thyroid (6) Neuro system & ENT (7)

Use the Mirari Cold Plasma device to treat Leukemia effectively.

WARNING: MIRARI COLD PLASMA IS DESIGNED FOR THE HUMAN BODY WITHOUT ANY ARTIFICIAL OR THIRD PARTY PRODUCTS. USE OF OTHER PRODUCTS IN COMBINATION WITH MIRARI COLD PLASMA MAY CAUSE UNPREDICTABLE EFFECTS, HARM OR INJURY. PLEASE CONSULT A MEDICAL PROFESSIONAL BEFORE COMBINING ANY OTHER PRODUCTS WITH USE OF MIRARI.

Step 1: Cleanse the Skin

• Start by cleaning the affected area of the skin with a gentle cleanser or mild soap and water. Gently pat the area dry with a clean towel.

Step 2: Prepare the Mirari Cold Plasma device

• Ensure that the Mirari Cold Plasma device is fully charged or has fresh batteries as per the manufacturer’s instructions. Make sure the device is clean and in good working condition.
• Switch on the Mirari device using the power button or by following the specific instructions provided with the device.
• Some Mirari devices may have adjustable settings for intensity or treatment duration. Follow the manufacturer’s instructions to select the appropriate settings based on your needs and the recommended guidelines.

Step 3: Apply the Device

• Place the Mirari device in direct contact with the affected area of the skin. Gently glide or hold the device over the skin surface, ensuring even coverage of the area experiencing.
• Slowly move the Mirari device in a circular motion or follow a specific pattern as indicated in the user manual. This helps ensure thorough treatment coverage.

Step 4: Monitor and Assess:

• Keep track of your progress and evaluate the effectiveness of the Mirari device in managing your Leukemia. If you have any concerns or notice any adverse reactions, consult with your health care professional.

Note

This guide is for informational purposes only and should not replace the advice of a medical professional. Always consult with your healthcare provider or a qualified medical professional for personal advice, diagnosis, or treatment. Do not solely rely on the information presented here for decisions about your health. Use of this information is at your own risk. The authors of this guide, nor any associated entities or platforms, are not responsible for any potential adverse effects or outcomes based on the content.

Mirari Cold Plasma System Disclaimer

• Purpose: The Mirari Cold Plasma System is a Class 2 medical device designed for use by trained healthcare professionals. It has received clearance from the U.S. FDA and is registered for use in Thailand and Vietnam. It is not intended for use outside of these locations.
• Informational Use: The content and information provided with the device are for educational and informational purposes only. They are not a substitute for professional medical advice or care.
• Variable Outcomes: While the device is approved for specific uses, individual outcomes can differ. We do not assert or guarantee specific medical outcomes.
• Consultation: Prior to utilizing the device or making decisions based on its content, it is essential to consult with a Certified Mirari Tele-Therapist and your medical healthcare provider regarding specific protocols.
• Liability: By using this device, users are acknowledging and accepting all potential risks. Neither the manufacturer nor the distributor will be held accountable for any adverse reactions, injuries, or damages stemming from its use.
• Geographical Availability: This device has received approval for designated purposes by the Thai and Vietnam FDA. As of now, outside of Thailand and Vietnam, the Mirari Cold Plasma System is not available for purchase or use.

References

1. Medentic. (2024). ICD-10 – C95.9: Leukaemia, unspecified. https://www.medentic.app/en/resources/icd-codes/c95-9
2. Medentic. (2025). ICD-10 – C95: Leukaemia of unspecified cell type. https://www.medentic.app/en/resources/icd-codes/c95
3. PENCS. (2020). ICPC-2 PLUS GROUPERS ZEDMED. https://help.pencs.com.au/display/ADM/ICPC-2+PLUS+GROUPERS+ZEDMED
4. Tebbi CK. (2021). Etiology of Acute Leukemia: A Review. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC8125807/
5. Medical News Today. (2024). Is leukemia hereditary? Role of genetics, risk factors, and prevention. https://www.medicalnewstoday.com/articles/325332
6. Yale Medicine. (2022). Diagnosing Leukemia. https://www.yalemedicine.org/conditions/leukemia-diagnosis
7. Tripathi AK. (2025). Laboratory Evaluation of Acute Leukemia – StatPearls. NCBI. https://www.ncbi.nlm.nih.gov/books/NBK611988/
8. Memorial Sloan Kettering Cancer Center. (2024). Leukemia Diagnosis. https://www.mskcc.org/cancer-care/types/leukemias/diagnosis
9. Zhao Z, et al. (2020). Applications of PET in Diagnosis and Prognosis of Leukemia. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC7476341/
10. Al-Ibraheem A, et al. (2024). PET/CT in leukemia: utility and future directions. https://www.binasss.sa.cr/bibliotecas/bhm/jul24/38.pdf
11. AboutKidsHealth. (2018). Leukemia and lumbar puncture. https://www.aboutkidshealth.ca/leukemia-and-lumbar-puncture
12. Blood Cancer United. (2004). Lumbar Puncture. https://bloodcancerunited.org/lab-and-imaging-tests/lumbar-puncture
13. Bookimed. (2024). How Much Does Leukemia Treatment Cost. https://us-uk.bookimed.com/article/how-much-leukemia-treatment-costs/
14. Baek DW, et al. (2023). Rituximab plus multiagent chemotherapy for newly diagnosed CD20-positive acute lymphoblastic leukemia. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC10493456/
15. Broder MS, et al. (2017). The Cost of Hematopoietic Stem-Cell Transplantation in the United States. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC5726064/
16. Wesa K, et al. (2009). Is there a role for complementary therapy in haematological malignancy? PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC2792198/
17. WebMD. (2025). Chronic Lymphocytic Leukemia: Complementary Therapy. https://www.webmd.com/cancer/lymphoma/cll-complementary-therapies