Understanding Steroid Withdrawal Rash and Eczema Flare-Ups

May 26, 2024

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If you’ve been using topical corticosteroids to manage your eczema or another inflammatory skin condition, you may have experienced a steroid withdrawal rash or worsening eczema symptoms when trying to stop the medication. This uncomfortable and sometimes painful reaction, known as topical steroid withdrawal (TSW) or “red skin syndrome,” can be frustrating and confusing to deal with.

In this article, we’ll dive deep into the causes, symptoms, and management of steroid withdrawal skin rashes and eczema flare-ups related to stopping topical steroids. Whether you’re considering tapering off your medication or are in the midst of a withdrawal reaction, understanding what to expect and how to cope can help you navigate this challenging process.

What is a Steroid Withdrawal Rash?

A steroid withdrawal rash is a type of skin irritation that can occur when you stop using topical corticosteroids after a prolonged period of use. Topical steroids are medicated creams, ointments, or lotions that are applied directly to the skin to reduce inflammation and irritation. They are commonly prescribed to treat eczema, psoriasis, and other skin conditions.

While topical steroids can be very effective at controlling symptoms in the short term, long-term use can sometimes lead to adverse effects, including skin thinning, changes in pigmentation, and a phenomenon known as “rebound” or “withdrawal” dermatitis[1].

Steroid withdrawal rashes can range from mild to severe and may include symptoms like:

  • Redness and flushing of the skin
  • Burning and stinging sensations
  • Intense itching
  • Skin peeling and flaking
  • Swelling and puffiness, especially on the face
  • Oozing and weeping of clear fluid from the skin
  • Skin sensitivity and tenderness to touch

These symptoms often appear within days to weeks of stopping the topical steroid and can be more severe and widespread than the original skin condition being treated[1].

Topical Steroid Rebound Rash

One specific type of steroid withdrawal rash is known as a topical steroid rebound rash or “rebound dermatitis.” This occurs when the skin becomes so used to the anti-inflammatory effects of the topical steroid that it can’t function normally without it. When the medication is stopped, the skin experiences a sudden flare-up of inflammation and irritation, often spreading beyond the original treatment area[1].

Rebound rashes are more likely to occur with higher-potency topical steroids and after longer durations of use. They can be very distressing and may require additional treatment to manage symptoms.

Red Skin Syndrome (RSS) and TSW

In severe cases, steroid withdrawal can cause a condition known as Red Skin Syndrome (RSS) or Red Man Syndrome. This is an intense, full-body reaction characterized by bright red, burning, and itchy skin that can be extremely painful and debilitating. Other symptoms of RSS may include:

  • Severe swelling and edema, especially on the face and genitals
  • Oozing and crusting of the skin
  • Skin shedding and peeling in large sheets
  • Lymph node swelling and flu-like symptoms
  • Insomnia and fatigue due to discomfort and itching

RSS is considered a more advanced stage of TSW and can take months to years to fully resolve. It often requires careful management under the guidance of a dermatologist specializing in TSW.

Eczema Withdrawal Symptoms

For people with eczema (atopic dermatitis), stopping topical steroids can be especially challenging. Eczema is a chronic, inflammatory skin condition that causes dry, itchy, and inflamed skin. It is often managed with a combination of moisturizers, topical steroids, and other anti-inflammatory medications.

When eczema patients use topical steroids for a long time and then try to stop them, they may experience a severe worsening of their eczema symptoms, known as steroid-dependent eczema or eczema withdrawal[2]. This can happen even with low-potency steroids and can be very distressing.

Symptoms of eczema withdrawal may include:

  • Intense itching and scratching, often worse at night
  • Redness and inflammation that spreads beyond the original eczema patches
  • Burning and stinging sensations on the skin
  • Dry, flaky, and peeling skin
  • Oozing and weeping of clear fluid or pus
  • Skin thickening and lichenification (leathery texture) from chronic scratching
  • Painful cracks and fissures, especially on the hands and feet

In some cases, eczema withdrawal can also cause eczema herpeticum, a rare but serious complication caused by the herpes simplex virus. This appears as clusters of small, painful blisters that can spread quickly and may require immediate medical attention[2].

Managing eczema withdrawal often involves a combination of gentle skin care, moisturizers, and non-steroid medications to control inflammation and itch. Working closely with a dermatologist who understands TSW can help you develop a personalized treatment plan.

Differentiating Steroid Withdrawal from an Allergic Reaction

It’s important to note that not all rashes that appear after stopping topical steroids are necessarily due to withdrawal. In some cases, you may be experiencing an allergic reaction to one of the ingredients in the medication, such as preservatives or fragrances.

Allergic contact dermatitis from topical steroids can cause symptoms like:

  • Itching and burning of the skin
  • Redness and swelling in the area where the medication was applied
  • Blisters or hives (raised, itchy bumps)

If you suspect an allergic reaction to your topical steroid or any other skincare product, stop using it immediately and contact your dermatologist. They can perform patch testing to identify the specific allergen and recommend alternative treatments.

Diagnosing Steroid Withdrawal Rash and Eczema Flare-Ups

Diagnosing steroid withdrawal can be tricky because the symptoms can mimic those of other skin conditions, such as eczema, psoriasis, or contact dermatitis. There is no specific test for TSW, so diagnosis relies on a thorough medical history and physical examination by a knowledgeable dermatologist.

Some key factors that suggest TSW include:

  • History of prolonged topical steroid use, especially on the face or genital area
  • Worsening of skin symptoms within days to weeks of stopping the medication
  • Burning and stinging sensations that are out of proportion to the visible rash
  • Spreading of the rash to areas where the steroid was not originally applied
  • Failure to respond to usual eczema or psoriasis treatments

Your dermatologist may also perform a skin biopsy to rule out other conditions, such as fungal infections or cutaneous T-cell lymphoma, that can mimic the appearance of TSW.

It’s important to find a dermatologist who is familiar with diagnosing and treating TSW, as many healthcare providers may not be aware of this condition or may misdiagnose it as an eczema flare-up or psoriasis.

Treating Steroid Withdrawal Rash and Eczema

The management of steroid withdrawal rash and eczema flare-ups depends on the severity of your symptoms and the duration of your topical steroid use. In general, treatment involves stopping the topical steroid medication and providing supportive care to help manage symptoms during the withdrawal process.

Tapering Off Topical Steroids

In some cases, your dermatologist may recommend gradually tapering off your topical steroid rather than stopping it abruptly. This involves using a lower-potency steroid or applying it less frequently over a period of weeks to months, depending on your individual case.

Tapering can help minimize the severity of withdrawal symptoms and allow your skin time to adjust to the absence of the medication. However, it’s important to note that tapering does not always prevent withdrawal symptoms entirely, and some people may still experience a rebound rash or flare-up of their underlying skin condition[1].

Cold Turkey Withdrawal

For others, stopping topical steroids “cold turkey” may be recommended, especially if you’ve only been using them for a short period or have been using a low-potency steroid. This involves completely discontinuing the medication and allowing your skin to go through the withdrawal process without any further exposure to topical steroids.

Cold turkey withdrawal can be more intense and uncomfortable than tapering, but it may also lead to faster resolution of symptoms in the long run. Your dermatologist can help you weigh the pros and cons of each approach and develop a plan that works best for your individual situation.

Gentle Skin Care During Withdrawal

Regardless of whether you’re tapering or stopping cold turkey, practicing gentle skin care is essential to support your skin during the withdrawal process. This includes:

  • Using lukewarm water for bathing and showering, as hot water can further dry and irritate your skin
  • Applying fragrance-free, hypoallergenic moisturizers multiple times a day to help soothe and protect your skin barrier
  • Avoiding harsh soaps, exfoliants, and other potentially irritating skincare products
  • Wearing loose, breathable clothing to minimize friction and irritation
  • Using a humidifier to add moisture to the air and prevent excessive drying of your skin

Your dermatologist may also recommend specific moisturizers or barrier repair creams to help speed up the healing process and relieve symptoms like itching and burning.

Wet Wrap Therapy for Severe Symptoms

For severe cases of TSW or eczema withdrawal, your dermatologist may recommend wet wrap therapy to help soothe and hydrate your skin. This involves applying a layer of moisturizer or emollient to your skin, then covering it with a layer of damp gauze or clothing (such as cotton pajamas or gloves) and sealing it with a dry layer on top.

Wet wraps can help increase the penetration of moisturizer into your skin, reduce inflammation and itching, and protect your skin from further irritation. They are typically left on for several hours or overnight and can be repeated daily or as needed under the guidance of your dermatologist.

Medications for Itch and Inflammation

To help manage the intense itching and inflammation associated with TSW and eczema withdrawal, your dermatologist may prescribe one or more of the following medications:

  • Oral antihistamines, such as diphenhydramine (Benadryl) or hydroxyzine (Atarax), to help reduce itching and improve sleep
  • Topical calcineurin inhibitors, such as tacrolimus (Protopic) or pimecrolimus (Elidel), which are non-steroid medications that can help reduce inflammation and itching
  • Oral corticosteroids, such as prednisone, which may be used in severe cases to quickly reduce inflammation and itching (but should be used with caution due to potential side effects)
  • Antibiotics, either topical or oral, if there are signs of secondary bacterial infection on the skin

It’s important to use these medications only as directed by your dermatologist and to be aware of potential side effects. Overuse of oral corticosteroids, in particular, can lead to additional withdrawal symptoms when stopped.

Phototherapy for Persistent Symptoms

For some people with TSW or eczema withdrawal, symptoms may persist despite gentle skin care and medications. In these cases, your dermatologist may recommend phototherapy, which involves exposing your skin to controlled amounts of ultraviolet (UV) light to help reduce inflammation and promote healing.

The most common type of phototherapy used for TSW and eczema is narrowband UVB (NB-UVB) therapy, which uses a specific wavelength of UV light that is less likely to cause skin damage than other types of UV light. NB-UVB therapy is typically performed in a dermatologist’s office or at a specialized phototherapy center, and requires multiple sessions per week for several weeks to see improvement.

Phototherapy can be an effective adjunctive treatment for TSW and eczema, but it may not be appropriate for everyone. It can also have potential side effects, such as skin dryness, itching, and increased risk of skin cancer with long-term use. Your dermatologist can help you determine if phototherapy is a good option for your individual case.

Coping with the Emotional Impact of Steroid Withdrawal

In addition to the physical symptoms of TSW and eczema withdrawal, many people also experience significant emotional distress during the withdrawal process. The constant itching, pain, and visible skin changes can be isolating and frustrating, leading to feelings of depression, anxiety, and low self-esteem.

Some strategies that may help you cope with the emotional impact of TSW include:

  • Seeking support from loved ones, whether it’s practical help with daily tasks or simply a listening ear when you need to vent
  • Connecting with others who have gone through TSW through online support groups, such as the ITSAN (International Topical Steroid Awareness Network) forum or social media groups
  • Practicing stress-management techniques, such as deep breathing, meditation, or gentle exercise, to help reduce anxiety and promote relaxation
  • Focusing on self-care activities that bring you joy and comfort, such as reading, listening to music, or spending time in nature
  • Working with a therapist who specializes in chronic skin conditions and can provide additional coping strategies and support

Remember that healing from TSW and eczema withdrawal is a gradual process, and it’s normal to have ups and downs along the way. Be patient with yourself and celebrate the small victories as your skin begins to heal.

When to Seek Medical Attention

While some degree of discomfort and skin changes are to be expected during TSW and eczema withdrawal, there are certain symptoms that warrant prompt medical attention. Contact your dermatologist or seek emergency care if you experience any of the following:

  • Signs of skin infection, such as sudden worsening of redness, swelling, pain, or oozing of pus
  • Fever or chills along with your skin symptoms
  • Severe swelling of the face, lips, or tongue that may indicate an allergic reaction
  • Difficulty breathing or swallowing
  • Suicidal thoughts or severe depression that interferes with your daily functioning

Your dermatologist can help you assess the severity of your symptoms and determine if additional treatment or referral to another specialist is necessary.

Preventing Steroid Withdrawal and Eczema Flare-Ups

The best way to prevent steroid withdrawal and eczema flare-ups is to use topical steroids judiciously and under the close supervision of a dermatologist. Some tips for minimizing your risk of developing TSW include:

  • Using the lowest potency steroid needed to control your symptoms, for the shortest duration possible
  • Applying a thin layer of the steroid only to affected areas of skin, not to healthy skin
  • Following your dermatologist’s instructions for frequency and duration of use
  • Avoiding long-term use of topical steroids on sensitive areas, such as the face, genitals, and skin folds
  • Monitoring for signs of skin thinning, easy bruising, or stretch marks, which can indicate overuse of topical steroids
  • Using non-steroid treatments, such as moisturizers and topical calcineurin inhibitors, to help control eczema symptoms and reduce the need for topical steroids

If you have been using topical steroids for a long time and are concerned about the risk of withdrawal, talk to your dermatologist about developing a personalized plan for tapering off the medication safely.

The Bottom Line

Steroid withdrawal rash and eczema flare-ups can be challenging and distressing to deal with, but with proper medical guidance and support, it is possible to get through the withdrawal process and achieve healthier, more resilient skin.

If you suspect that you may be experiencing TSW or an eczema flare-up related to topical steroid use, don’t hesitate to reach out to a dermatologist who is knowledgeable about these conditions. They can help you develop a personalized treatment plan that addresses your specific symptoms and concerns.

Remember, everyone’s journey with TSW and eczema is unique, and what works for one person may not work for another. Be patient with yourself and your skin, and don’t hesitate to seek support from loved ones, healthcare providers, and the TSW community as you navigate this challenging process.

Key Points

  • Steroid withdrawal rash and eczema flare-ups can occur when topical corticosteroids are stopped after prolonged use, leading to red, burning, itchy skin and other uncomfortable symptoms.
  • Symptoms of TSW can range from mild to severe and may include intense itching, skin peeling and flaking, swelling, and oozing.
  • Eczema patients are particularly susceptible to TSW and may experience a severe worsening of their symptoms when stopping topical steroids.
  • Diagnosis of TSW relies on a thorough medical history and physical examination by a knowledgeable dermatologist, as there is no specific test for the condition.
  • Treatment of TSW and eczema withdrawal typically involves discontinuing the topical steroid (either through tapering or cold turkey), gentle skin care, and medications to manage itch and inflammation.
  • Phototherapy and wet wrap therapy may be helpful for more severe or persistent cases of TSW and eczema withdrawal.
  • The emotional impact of TSW can be significant, and it’s important to seek support from loved ones, healthcare providers, and the TSW community.
  • Preventing TSW and eczema flare-ups involves using topical steroids judiciously, under the guidance of a dermatologist, and monitoring for signs of overuse.
  • If you suspect you may be experiencing TSW or an eczema flare-up related to topical steroid use, seek evaluation and guidance from a knowledgeable dermatologist.

Frequently Asked Questions

How long does steroid withdrawal rash last?

The duration of steroid withdrawal rash varies from person to person, but symptoms can persist for weeks to months after stopping the medication. In some severe cases, full recovery may take up to 1-2 years. Working closely with a dermatologist and practicing gentle skin care can help support the healing process.

Can I use moisturizers or other topical treatments during steroid withdrawal?

Yes, using gentle, fragrance-free moisturizers and emollients is an important part of managing steroid withdrawal rash and supporting skin barrier function. Your dermatologist may also recommend specific topical treatments, such as calcineurin inhibitors, to help control inflammation and itch. However, it’s important to avoid any products that contain steroids or other potential irritants.

Is steroid withdrawal rash contagious?

No, steroid withdrawal rash is not contagious. It is an individual reaction to the discontinuation of topical corticosteroids and cannot be spread from person to person.

Can diet affect steroid withdrawal rash or eczema?

While there is no specific “steroid withdrawal diet,” some people find that certain foods may trigger or worsen their symptoms. Common culprits include dairy, gluten, sugar, and processed foods. Keeping a food diary and working with a registered dietitian may help identify potential triggers. However, it’s important to note that dietary changes alone are unlikely to resolve steroid withdrawal rash or eczema.

Are there any natural remedies for steroid withdrawal rash or eczema?

Some people find relief from steroid withdrawal rash and eczema symptoms with natural remedies, such as colloidal oatmeal baths, aloe vera gel, or coconut oil. However, it’s important to talk to your dermatologist before trying any new treatments, as some natural remedies may actually worsen your symptoms or interact with your prescribed medications. Your dermatologist can help you determine which remedies may be safe and effective for your individual case.

If you’re struggling with steroid withdrawal rash or eczema flare-ups, know that you’re not alone. With the right medical guidance, self-care strategies, and support from loved ones and the TSW community, it is possible to get through this challenging time and emerge with healthier, more resilient skin. Don’t hesitate to reach out for help when you need it, and remember to be kind to yourself as you navigate the ups and downs of the healing process.


  1. Sheary, B. (2018). Topical steroid addiction and withdrawal-An overview for GPs. Australian family physician, 47(10), 668-671.
  2. Hajar, T., Leshem, Y. A., Hanifin, J. M., Nedorost, S. T., Lio, P. A., Paller, A. S., … & Simpson, E. L. (2015). A systematic review of topical corticosteroid withdrawal (“steroid addiction”) in patients with atopic dermatitis and other dermatoses. Journal of the American Academy of Dermatology, 72(3), 541-549.
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