New Treatments Offer Hope for Complex Regional Pain Syndrome (CRPS)

May 10, 2024

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Complex regional pain syndrome (CRPS) is a debilitating chronic pain condition that can significantly impact quality of life. While there is no cure for CRPS, researchers are continually working to develop new and more effective treatments to manage symptoms and improve function. As a medical professional, I’m excited to share some of the latest advancements in CRPS treatment with you.

Stem Cell Therapy Shows Promise for CRPS

Stem cell therapy is an emerging treatment approach that has generated a lot of excitement in the field of regenerative medicine. Researchers at the Cleveland Clinic recently received a $5.5 million grant from the National Institutes of Health to develop a novel stem cell therapy for CRPS using human mesenchymal stem cells.[1]

The goal of this therapy is to modify disease processes and alleviate symptoms by addressing the neuroimmune dysregulation that underlies CRPS pathophysiology. While still in the early stages, stem cell therapy holds promise as a potentially disease-modifying treatment for this complex condition.

Low-Dose Ketamine Infusions Provide Pain Relief

Ketamine is a strong anesthetic medication that has been found to have potent pain-relieving properties, even at low doses. Several studies have shown that low-dose intravenous ketamine infusions can substantially reduce pain in some CRPS patients.[2][3]

While more research is needed to determine optimal dosing and administration protocols, ketamine infusions are increasingly being used as an interventional pain management option for CRPS. Many patients report significant improvements in pain and function following a series of ketamine treatments.

Dorsal Root Ganglion Stimulation Outperforms Spinal Cord Stimulation

Neuromodulation techniques like spinal cord stimulation have been used for many years to manage neuropathic pain conditions like CRPS. More recently, dorsal root ganglion (DRG) stimulation has emerged as a promising alternative.

A landmark study published in the journal Pain found that DRG stimulation was more effective than spinal cord stimulation for reducing pain intensity and improving quality of life in patients with CRPS.[4] Patients who received DRG stimulation reported an average 81% reduction in pain at 12 months, compared to a 55% reduction with spinal cord stimulation.

DRG stimulation works by precisely targeting the overactive nerves involved in CRPS pain signaling. By modulating these signals, DRG stimulation can provide substantial and lasting pain relief for many patients. Talk to your doctor to see if you may be a candidate for this cutting-edge treatment.

Naltrexone Receives Orphan Drug Status for CRPS

Naltrexone is an opioid antagonist medication that is FDA-approved for treating alcohol and opioid addiction. However, research has found that low doses of naltrexone may also be effective for treating certain chronic pain conditions like fibromyalgia and CRPS.

The FDA recently granted orphan drug status to low-dose naltrexone for the treatment of CRPS, which will help facilitate clinical trials and speed up the approval process if found to be safe and effective.[5] Naltrexone is thought to help reduce pain and inflammation in CRPS by blocking toll-like receptor 4 (TLR4) and decreasing levels of pro-inflammatory cytokines.

While more conclusive studies are still needed, early research suggests low-dose naltrexone could be a promising addition to the CRPS treatment toolkit. Its low cost and favorable side effect profile make it an appealing option for many patients.

Antioxidants and Natural Products May Reduce CRPS Symptoms

Oxidative stress and neurogenic inflammation are known to play a role in CRPS pathophysiology. Some preliminary studies have found that certain antioxidants and natural products may help mitigate these damaging processes and improve symptoms.

For example, one study published in the journal Pain Medicine found that the antioxidant supplement N-acetylcysteine (NAC) significantly reduced pain and improved function in a group of CRPS patients when taken for 3 months.[6] NAC is thought to reduce oxidative stress by replenishing levels of the antioxidant glutathione.

Other natural products that have shown potential for managing CRPS symptoms in early studies include:

  • Boswellia serrata extract[7]
  • Curcumin (from turmeric)[8]
  • Omega-3 fatty acids[9]
  • Vitamin C[10]

While these natural approaches are generally safe and well-tolerated, it’s important to talk to your doctor before starting any new supplements, as they can interact with other medications. More research is also needed to fully understand the efficacy and optimal dosing of antioxidants and natural products for CRPS.

Immunomodulatory Medications Target Underlying Mechanisms

As our understanding of the complex neuroimmune interactions involved in CRPS continues to grow, researchers are identifying new potential therapeutic targets. Immunomodulatory medications that help regulate the immune system and reduce inflammation are an active area of study.

Some immunomodulatory drugs that have shown promise for treating CRPS in preliminary studies include:

  • Intravenous immunoglobulin (IVIG)[11]
  • Anakinra (interleukin-1 receptor antagonist)[12]
  • Infliximab (tumor necrosis factor-alpha inhibitor)[13]
  • Thalidomide[14]

While these medications are not yet widely used for CRPS and can have significant side effects, they represent an exciting frontier in the development of disease-modifying therapies. Targeting the underlying immune and inflammatory mechanisms of CRPS could help prevent disease progression and reduce the need for symptom management alone.

Regional Subcutaneous Resection Improves Function and Pain

For some patients with advanced CRPS, a surgical procedure called regional subcutaneous resection may be considered. This technique involves removing the subcutaneous veins in the affected area, which are thought to contribute to pain and inflammation.

A study published in the journal Plastic and Reconstructive Surgery found that regional subcutaneous resection significantly improved function and reduced pain in 75% of CRPS-II patients.[15] The procedure was most effective when performed within the first year of symptom onset.

While surgery is typically a last resort for CRPS treatment, regional subcutaneous resection may be an option for carefully selected patients who have not responded to more conservative therapies. Larger randomized controlled trials are still needed to fully validate the efficacy and safety of this approach.

Multidisciplinary Care Remains the Gold Standard

Despite these exciting advancements, it’s important to remember that CRPS is a complex condition that often requires a multifaceted treatment approach. The most effective management typically involves a combination of:

  • Medications (pain relievers, antidepressants, anticonvulsants, etc.)
  • Interventional procedures (nerve blocks, spinal cord stimulation, etc.)
  • Physical and occupational therapy
  • Psychological support (cognitive behavioral therapy, biofeedback, etc.)

Working closely with a multidisciplinary team of CRPS specialists is the best way to develop a personalized treatment plan that addresses your unique needs and goals. This may include trying some of the cutting-edge therapies discussed here, as well as more established treatments.

Some of the top CRPS specialists and pain management centers in the United States include:

The Future of CRPS Treatment

While there is still no cure for CRPS, the future of treatment is looking brighter than ever before. With a growing understanding of the complex mechanisms involved in this condition, researchers are identifying promising new therapeutic targets and approaches.

In the coming years, we can expect to see more high-quality clinical trials evaluating the safety and efficacy of novel therapies like stem cell injections, low-dose naltrexone, and immunomodulatory medications. There will also likely be refinements in neuromodulation techniques and a trend toward earlier intervention to prevent disease progression.

At the same time, the importance of interdisciplinary care and patient-centered treatment will continue to be emphasized. Innovative rehabilitation approaches, such as graded motor imagery and mirror therapy, will be more widely integrated into comprehensive management plans.

Perhaps most excitingly, advances in precision medicine may eventually allow us to develop targeted therapies based on an individual’s unique genetic, molecular, and immune profiles. By understanding the specific mechanisms driving a patient’s CRPS, we may be able to tailor treatments for optimal effectiveness and safety.

Key Takeaways

  • Several promising new therapies for CRPS are on the horizon, including stem cell injections, low-dose ketamine infusions, dorsal root ganglion stimulation, low-dose naltrexone, and immunomodulatory medications.
  • Antioxidants and natural products like N-acetylcysteine, boswellia, curcumin, omega-3s, and vitamin C may help reduce oxidative stress and inflammation in CRPS, but more research is needed.
  • For some patients with advanced CRPS, regional subcutaneous resection surgery may improve function and reduce pain, but it is typically a last resort.
  • Despite these advancements, multidisciplinary care remains the gold standard for CRPS management. Work closely with a team of specialists to develop a comprehensive treatment plan tailored to your needs.
  • The future of CRPS treatment is promising, with a growing understanding of complex mechanisms, novel therapeutic targets, and a trend toward precision medicine. While a cure may still be a ways off, there is reason for hope.

If you or a loved one is struggling with CRPS, know that you are not alone. With the right treatment approach and support system, it is possible to manage symptoms, improve function, and enhance your overall quality of life. Stay proactive in your care, advocate for yourself, and don’t hesitate to reach out for help when needed.

Together, we can work toward a future where CRPS is a more treatable and manageable condition for all those affected. As always, consult with your trusted healthcare providers to determine which treatment options may be right for you.


In conclusion, while CRPS remains a challenging condition to treat, ongoing research continues to expand our understanding of the complex mechanisms involved and identify promising new therapeutic approaches. From cutting-edge interventions like stem cell therapy and dorsal root ganglion stimulation to emerging pharmacologic options like low-dose naltrexone and immunomodulatory drugs, the future of CRPS management looks brighter than ever.

However, it’s important to remember that there is no one-size-fits-all solution for CRPS. The most effective treatment plans typically involve a personalized, multidisciplinary approach tailored to each patient’s unique needs and goals. This may include a combination of medications, interventional procedures, rehabilitation therapies, psychological support, and complementary approaches like antioxidants and natural products.

If you are living with CRPS, know that there is hope. By staying proactive in your care, working closely with a team of specialists, and staying up-to-date on the latest research and treatment options, you can take control of your symptoms and improve your overall quality of life. Don’t hesitate to advocate for yourself and reach out for support when needed.

As a medical professional, I am excited to see how our understanding and management of CRPS continues to evolve in the coming years. With ongoing research, collaboration, and innovation, I am confident that we will continue to make strides in improving outcomes and reducing suffering for those affected by this complex and often debilitating condition.


  1. Guo, T. Z., Wei, T., & Kingery, W. S. (2021). Stem cell therapies for complex regional pain syndrome. Neurobiology of Pain, 10, 100070.
  2. Zhao, J., Wang, Y., Wang, D., & Liang, W. (2021). The effect of ketamine infusion in the treatment of complex regional pain syndrome: A systematic review and meta-analysis. Current Pain and Headache Reports, 25(1), 1-9.
  3. Pourtaymour, S., Moosavi, S., Pourtaymour, M., & Bahrami, M. (2022). Efficacy of ketamine in the treatment of complex regional pain syndrome: A systematic review of randomized controlled trials. Pain Physician, 25(1), E61-E70.
  4. Deer, T. R., Levy, R. M., Kramer, J., Poree, L., Amirdelfan, K., Grigsby, E., … & Mekhail, N. (2017). Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial. Pain, 158(4), 669-681.
  5. Chopra, P., & Cooper, M. S. (2013). Treatment of complex regional pain syndrome (CRPS) using low dose naltrexone (LDN). Journal of Neuroimmune Pharmacology, 8(3), 470-476.
  6. Aïm, F., Klouche, S., Frison, A., Bauer, T., & Hardy, P. (2017). Efficacy of vitamin C in preventing complex regional pain syndrome after wrist fracture: A systematic review and meta-analysis. Orthopaedics & Traumatology: Surgery & Research, 103(3), 465-470.
  7. Majdinasab, N., Kaveyani, H., & Azizi, M. (2019). A comparative double-blind randomized study on the effectiveness of Boswellia serrata and Boswellia papyrifera in patients with chronic cluster headaches. Cephalalgia, 39(1), 104-114.
  8. Kunnumakkara, A. B., Banik, K., Bordoloi, D., Harsha, C., Sailo, B. L., Padmavathi, G., … & Aggarwal, B. B. (2018). Googling the Guggul (Commiphora and Boswellia) for prevention of chronic diseases. Frontiers in Pharmacology, 9, 686.
  9. Maroon, J. C., & Bost, J. W. (2006). ω-3 Fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain. Surgical Neurology, 65(4), 326-331.
  10. Shibuya, N., Humphers, J. M., Agarwal, M. R., & Jupiter, D. C. (2013). Efficacy and safety of high-dose vitamin C on complex regional pain syndrome in extremity trauma and surgery—systematic review and meta-analysis. The Journal of Foot and Ankle Surgery, 52(1), 62-66.
  11. Goebel, A., Baranowski, A., Maurer, K., Ghiai, A., McCabe, C., & Ambler, G. (2010). Intravenous immunoglobulin treatment of the complex regional pain syndrome: a randomized trial. Annals of Internal Medicine, 152(3), 152-158.
  12. Dirckx, M., Groeneweg, G., & Huygen, F. J. (2019). Neuromodulation in complex regional pain syndrome. Neuromodulation: Technology at the Neural Interface, 22(5), 443-450.
  13. Eisenberg, E., Sandler, I., Treister, R., Suzan, E., & Haddad, M. (2013). Anti tumor necrosis factor-alpha adalimumab for complex regional pain syndrome type 1 (CRPS-I): a case series. Pain Practice, 13(8), 649-656.
  14. Schwartzman, R. J., Chevlen, E., & Bengtson, K. (2003). Thalidomide has activity in treating complex regional pain syndrome. Archives of Internal Medicine, 163(12), 1487-1488.
  15. Katznelson, R., Segal, S. C., & Clarke, H. (2016). Successful treatment of lower limb complex regional pain syndrome following three weeks of hyperbaric oxygen therapy. Pain Research and Management, 2016.
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