Can Mupirocin Treat Molluscum Lesions or Just Co-Infections?

May 18, 2024

Featured image for “Can Mupirocin Treat Molluscum Lesions or Just Co-Infections?”

Frustrating molluscum outbreaks afflicting both children and adults often lead patients to try an array of creams aiming to smooth bumps faster. Some may wonder whether antibiotic ointments like mupirocin (Bactroban) can treat molluscum itself, or just secondary infections that may emerge.

What does current evidence actually indicate about using mupirocin for molluscum contagiosum?

Overview of Molluscum Contagiosum

Molluscum contagiosum refers to a viral pox infection transmitted through skin-to-skin contact. After an incubation period of 2-7 weeks, small flesh-colored papules emerge that may itch slightly. Lesions eventually open, revealing indented centers with cottage cheese-like cores.

Without treatment, molluscum bumps generally clear within 6-12 months. But patients often seek ways to speed resolution, reduce scarring from scratching, and prevent further spreading.

Goals of Molluscum Home Treatment

As molluscum is self-limiting, therapy mainly focuses on managing bothersome lesions through:

  • Soothing redness, inflammation and itch
  • Preventing picking/scratching to avoid scars
  • Keeping lesions clean and covered
  • Allowing bumps to run their course

But no over-the-counter items treat underlying viral infections. They only temporarily improve symptoms in the meantime.

Mupirocin Mechanism and Uses

Mupirocin is a topical antibiotic ointment applied directly on skin infections to clear bacteria like:

  • Staphylococcus aureus
  • Streptococcus pyogenes
  • Gram positive organisms

It works by inhibiting bacterial protein synthesis to stop growth and spread of pathogens. But mupirocin has no antiviral activity.

Common brand names are Bactroban or Centany. It comes as a 2% skin cream, gel or ointment.

Can Mupirocin Treat Molluscum Lesions?

No, mupirocin cannot resolve or eliminate molluscum contagiosum virus infection itself. It is not antiviral. But it may help curb secondary complications like:

  • Bacterial folliculitis
  • Cellulitis
  • Localized skin infections

If molluscum papules rupture, scratch open or ooze, bacterial superinfections can develop in damaged areas. Applying mupirocin then prevents further expansion and symptoms. But it does not speed drying core viral lesions.

Appropriate Use of Mupirocin With Molluscum

Using mupirocin aims to control isolated co-occurring bacterial spread on the skin surface near viral molluscum lesions. Signs of superinfection warranting antibiotic ointment include:

  • Expanding honey-colored crusting
  • Increasing redness, pain, warmth
  • Enlarged lymph nodes
  • Systemic fever, malaise

Dab mupirocin gently on molluscum papules at first evidence of rupturing, weeping, or crusting once daily. Reevaluate in 5-7 days, continuing if infected. But do not apply antivirals hoping to treat viral bumps.

Always use minimal doses needed for symptom control. Antibiotic overuse risks resistance. Have patience allowing natural viral clearance simultaneously.

At-Home Treatment Expectations and Limits

Experimenting with home molluscum remedies tends to yield partial short-term improvements along with some key drawbacks:


  • Temporary bump drying/flattening
  • Brief relief from inflammation itching
  • Preventing bacterial spread


  • Cannot kill internal contagion itself
  • High risk of lesion recurrence
  • No lasting infection eradication
  • Wasting money on ineffective items

Have realistic expectations about over-the-counter products alone concealing bumps temporarily without addressing core viral reservoirs. Combining clinical care with home soothing aims for more lasting viral destruction.

Signs Needing Stronger Medical Treatment

While conservative initial management suits many molluscum cases, worsening symptoms warrant prescription therapy when experiencing:

  • Sudden eruption of 20+ new lesions uncontrolled
  • Highly inflamed, expanding, oozing or crusted-over bumps
  • Impaired immunity unable to resolve
  • Unmanageable picking/scratching
  • Growths persisting 12+ months

Declining cases require customized clinical plans using medications like:

  • Cryotherapy freezing – liquid nitrogen destroying lesions
  • Cantharidin – topical blistering chemical treatment
  • Curettage – scraping or cutting off individual bumps
  • Candida antigen injections – stimulates immune reaction
  • Imiquimod cream – immune response modifier

Have providers reassess worsening molluscum to direct suitable antiviral treatment.

Frequently Asked Questions

Does mupirocin speed up drying molluscum lesions out?

No. While mupirocin can prevent secondary infections, it cannot resolve viral molluscum lesions themselves. It has no antiviral properties against the contagious poxvirus. Lesions still run their standard 6-12 month course.

If a molluscum bump oozes, should I apply antibiotic ointment?

Yes, weeping molluscum papules suggest likely bacterial superinfection, especially if surrounding skin looks expanding, red, warm or tender. Gently dab on mupirocin to control localized spread but avoid poking intact lesions open.

Can using mupirocin on molluscum bumps prevent later recurrence?

Unfortunately no. Mupirocin only aims to curb bacterial infections around irritated viral lesions. It does not eradicate molluscum contagiosum virus lurking internally to prevent eventual reemergence later after initial bumps resolve. More total destruction modalities are required.

Would oral antibiotics work better than topical mupirocin for infected molluscum?

Yes, for rapidly worsening diffuse surrounding cellulitis and folliculitis, systemic oral antibiotics often work better controlling extensive superinfections related to ruptured molluscum. But again – no antibiotics can speed resolving core viral lesions themselves.

Does applying antibiotic cream on molluscum lesions contribute to resistance?

Possibly. While judicious use of mupirocin is appropriate for infected weepy blisters, overuse on intact viral bumps is not indicated and can promote antibiotic resistance. Use minimally only where clearly clinically necessary.


  • Mupirocin cannot resolve molluscum contagiosum viruses
  • It aims to control secondary bacterial infections
  • Typical lesions still run their standard 6-12 month course
  • Oral antibiotics treat worsening diffuse infections
  • Combining approaches best manages symptoms

Use mupirocin appropriately only for clearly infected molluscum rather than intact viral lesions themselves. Have patience allowing natural regression simultaneously and avoid overuse breeding resistance.

Rate this post


Cold Plasma System

The world's first handheld cold plasma device

Learn More

Made in USA