Mastering Chemotherapy and Immunotherapy: Guidelines and Best Practices

March 3, 2024

Featured image for “Mastering Chemotherapy and Immunotherapy: Guidelines and Best Practices”

The treatment of cancer continues to rapidly evolve, with new targeted therapies and immunotherapies transforming outcomes for many patients. As the complexity of therapeutic options grows, it becomes increasingly vital for all healthcare professionals involved to thoroughly understand proper administration and side effect management. To provide optimal cancer care, staying up-to-date with the latest evidence-based recommendations and best practices is essential.

Understanding the Fundamentals

Getting the basics right forms the foundation for safely navigating patients through modern chemotherapy and immunotherapy.

Chemotherapy: Mechanisms of Action and Administration

“Chemotherapy uses powerful drugs to destroy rapidly dividing cancer cells.”

As described in this National Cancer Institute quote, traditional cytotoxic chemotherapy targets all rapidly proliferating cells. Various classifications of agents like alkylating agents, anthracyclines, and antimetabolites work through differing mechanisms to disrupt cancer cell division and growth.

Depending on the protocol, chemotherapy administration may involve regular intravenous infusions over hours through central lines or take-home oral anticancer medications. Strict adherence to prescribed doses and schedules helps maximize treatment benefits.

Immunotherapy: Empowering the Immune System

“Immunotherapy harnesses the body’s immune system to fight cancer cells.”

Rather than directly attacking tumors, the groundbreaking approach highlighted by this American Cancer Society quote uses our natural defenses against disease. Treatments like immune checkpoint inhibitors, CAR T-cell therapy, and therapeutic vaccines all aim to enhance anticancer immune activity.

Mapping the complex new landscape of immunotherapies, their molecular targets, optimal administration, and synergies with other cancer treatments leads to improved patient outcomes. Staying abreast of new approvals and updated usage guidelines is essential.

Guidelines and Recommendations for Practice

Evidence-based protocols for safely administering chemotherapy and the growing number of immunotherapies provide crucial guardrails.

ONS Chemotherapy and Immunotherapy Guidelines

“The ONS Chemotherapy and Immunotherapy Guidelines provide evidence-based recommendations for safe and effective administration.”

As this Oncology Nursing Society quote summarizes, the ONS guidelines compiled by experts guide appropriate patient selection, premedication, dose calculation, adverse event management, and other practical aspects of treatment. They represent an indispensable manual for optimizing processes and decision-making around cancer therapy administration.

Staying Up-to-Date with Best Practices

Given the breakneck speed of advances in oncology, healthcare professionals must actively incorporate new findings and recommendations into their practice. Attending conferences, pursuing continuing education, participating in research, and reading leading publications all help update skills to align with evolving standards.

Assessment and Preparation

Before initiating treatment, a thorough individualized assessment of the patient and their cancer helps match the regimen to their needs and prepares them for the road ahead.

Patient Assessment and Education

A holistic assessment evaluates the pathology, genomics, comorbidities, performance status, emotional state, social support system and more to guide suitable treatment selection. Educating patients in common side effects equips patients to play an active role while establishing open communication channels with the care team.

Medication Preparation and Safe Handling

Stringent double-checking of drug types and dosages prevents catastrophic errors, while properly functioning infusion equipment containing appropriate tubing sets averts mechanical issues. Enforcing strict aseptic technique, labeling, documentation, spill management protocols and safe waste disposal prevents contamination and undue exposure.

Administration and Monitoring

As complex chemotherapy infusions and immunotherapies are delivered, diligent monitoring safeguards patients.

Safe and Effective Administration Techniques

Precision is paramount when injecting corrosive medications into central lines or Kehr tubes under IV pumps. Guidelines provide drug-specific recommendations on administration order, timing, premedications and post-hydration. Frequently reassessing and documenting vital signs and comfort level is mandatory.

Patient Monitoring and Management of Side Effects

Anticipating and promptly addressing treatment reactions maximizes patients’ quality of life. Carrying out evidence-based interventions to minimize pain, fatigue, GI symptoms, bleeding risk and susceptibility to infections makes all the difference. Adjusting doses or medications to balance disease control with tolerability may enhance continuity.

Importance of Communication and Collaboration

Maintaining open dialogue about symptoms, concerns and information needs is essential for patient wellbeing and engagement. Coordinating seamlessly across all care providers ensures continuity and minimizes errors from fragmented views or place-based treatment approaches.

FAQs (Frequently Asked Questions)

Here are answers to some common questions on safely administering chemotherapy and immunotherapy:

What qualifications are needed to administer chemotherapy/immunotherapy?

Typically 1+ years of oncology experience followed by certification demonstrating competency in safe preparation, handling and administration of antineoplastic medications guided by training on current ONS protocols.

Where can I find the latest ONS cancer treatment administration guidelines?

The ONS website contains its regularly updated recommendations, protocols and education resources on chemotherapy and immunotherapy administration.

How can I stay updated on cancer therapy advancements?

Reading key oncology journals, pursing CME courses, attending tumor board meetings and participating in research keeps healthcare professionals apprised of progress.

What are common chemotherapy and immunotherapy side effects?

While too numerous to list here, fatigue, pain, GI issues, and susceptibility to infection are very frequent. Have patients discuss their experiences and symptom management strategies with their oncologist and nurses.

How can I cope with the emotional weight of caring for seriously ill patients?

Prioritizing emotional self-care with support groups, counseling or stress reduction while celebrating small wins helps prevent burnout. Establish healthy professional boundaries while fully engaging each patient.


Mastering the swiftly changing art and science of administering chemotherapy and ever-more complex immunotherapies to treat cancer demands diligent lifelong learning. An unwavering commitment to patients’ wellbeing through safely and compassionately applying the latest evidence-based techniques enables optimal healing outcomes.


  • Gaining a strong understanding of chemotherapy and immunotherapy mechanisms, classifications and administration guides appropriate usage.
  • Adopting the comprehensive, regularly updated ONS protocols and recommendations ensures patient safety and optimal cancer care quality.
  • Through continuous learning and improvement fueled by cancer therapy innovations, healthcare professionals can fulfill their vital role in the fight against malignancies.
Rate this post

Related articles


Cold Plasma System

The world's first handheld cold plasma device

Learn More

Made in USA