Decoding the Causes of Topical Steroid Withdrawal

May 26, 2024

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Topical steroid withdrawal (TSW), also known as steroid addiction skin or red skin syndrome, is a serious condition that can occur when someone stops using topical corticosteroid medications after prolonged or inappropriate use[1]. While the exact prevalence is unknown, TSW can cause severe and debilitating symptoms that significantly impact quality of life.

If you or a loved one have been using topical steroids for a long time and are concerned about the possibility of withdrawal, it’s important to understand the complex factors that contribute to this condition. In this article, we’ll decode the underlying causes of TSW, exploring both the physiological and psychological aspects of steroid addiction and withdrawal. By gaining a deeper understanding of these mechanisms, you can be better equipped to prevent, recognize, and manage TSW.

What Causes Topical Steroid Withdrawal?

The primary cause of TSW is the prolonged, frequent, or inappropriate use of topical corticosteroids, especially high-potency ones[1][2]. Topical steroids are commonly prescribed to treat inflammatory skin conditions like eczema (atopic dermatitis) and psoriasis. While they can be very effective at reducing inflammation and controlling flares, long-term use can lead to changes in the skin that make it dependent on the medication.

Some specific factors that increase the risk of developing TSW include:

  • Using topical steroids for longer than 2-4 weeks continuously[1][4][8]
  • Applying steroids more than twice daily[4][8]
  • Using high-potency steroids like clobetasol propionate or betamethasone dipropionate[1][2]
  • Applying steroids to sensitive areas like the face, genitals, or skin folds[1][2]
  • Abruptly discontinuing the steroid rather than gradually tapering[1][4]
  • Having an underlying skin condition like eczema or psoriasis that requires long-term steroid use[1][4]
  • Individual susceptibility to steroid side effects, possibly due to genetic factors[1]

When topical steroids are used for an extended period, the skin becomes “addicted” to their anti-inflammatory effects. The blood vessels in the skin dilate, leading to redness and burning when the steroid is withdrawn[1][5]. The skin’s natural barrier function also becomes impaired, making it more susceptible to irritation, dryness, and infection.

The Role of Steroid Potency

The potency of the topical steroid plays a significant role in the risk of developing TSW. Topical steroids are classified into seven categories based on their strength, with class I being the most potent and class VII the least[1].

In general, the higher the potency of the steroid, the greater the risk of side effects like skin atrophy, telangiectasia (spider veins), and TSW[1]. However, even low-potency steroids can cause problems if used inappropriately or for too long.

Improper Application and TSW Risk

In addition to the potency of the steroid, the way it is applied to the skin can also influence the risk of TSW. Some common mistakes that can lead to overuse include:

  • Applying the steroid more frequently than prescribed
  • Using a larger amount than needed to cover the affected area
  • Applying the steroid to unaffected skin or sensitive areas like the face and genitals
  • Using multiple steroid preparations at the same time
  • Not following the recommended duration of treatment

It’s important to use topical steroids only as directed by a healthcare provider and to be cautious when applying them to delicate or thin skin. Overuse, even of low-potency steroids, can lead to steroid “redout” where the skin becomes red, burning, and inflamed[1].

Abrupt Discontinuation and TSW

One of the most significant risk factors for TSW is stopping topical steroids suddenly, rather than gradually tapering the dose. When steroids are used for a long time, the adrenal glands (which normally produce the body’s natural steroids) can become suppressed. Abruptly stopping the medication can cause a sudden drop in steroid levels, triggering a rebound effect.

Symptoms of steroid withdrawal usually appear within a few days to weeks of discontinuing the medication and can be more severe than the original skin condition being treated. They may spread to areas of the body where the steroid was never applied.

To minimize the risk of TSW, it’s important to work with a dermatologist on a tapering schedule when stopping long-term topical steroids. This involves gradually reducing the frequency and/or potency of the medication over a period of weeks to months, depending on the individual case[1]. In some cases, switching to a lower-potency steroid or non-steroidal topical medication may be recommended.

The Physiology of Steroid Addiction and Withdrawal

To fully understand the causes of TSW, it’s helpful to explore the physiological mechanisms behind steroid addiction and withdrawal. Topical corticosteroids work by binding to glucocorticoid receptors in the skin cells, which then enter the nucleus and regulate the expression of various genes involved in inflammation[5].

With prolonged use of topical steroids, several changes occur in the skin that contribute to the development of TSW:

  • Tachyphylaxis: The skin becomes less responsive to the anti-inflammatory effects of the steroid over time, requiring higher doses or more potent steroids to achieve the same result[5].
  • Receptor changes: The ratio of different types of glucocorticoid receptors in the skin cells shifts, with an increase in the beta form that is less responsive to steroids[5]. This change is thought to be more pronounced in people with a history of atopic dermatitis.
  • Decreased natural steroid production: The skin’s own production of cortisol is suppressed with long-term topical steroid use, making it more difficult for the skin to regulate inflammation on its own when the medication is stopped[5].
  • Increased nitric oxide: Steroid withdrawal leads to a rebound increase in nitric oxide production by the skin’s blood vessels, causing redness and vasodilation[5].
  • Barrier dysfunction: The skin barrier becomes compromised, allowing more water loss and entry of irritants and allergens that can trigger inflammation[5].

These physiological changes create a vicious cycle where the skin becomes increasingly dependent on topical steroids to control inflammation, while at the same time becoming more vulnerable to the side effects of these medications. When the steroids are discontinued, the skin is left in a hyper-responsive and unstable state, leading to the characteristic symptoms of TSW.

The Psychology of Steroid Addiction and Withdrawal

In addition to the physical aspects of TSW, there are also important psychological factors that can contribute to the development and maintenance of this condition. The visible skin changes and distressing symptoms of TSW can have a profound impact on a person’s mental health and quality of life.

Some common psychological effects of TSW include:

  • Anxiety and depression: The unpredictable and often severe nature of TSW symptoms can cause significant anxiety and low mood. People may feel self-conscious about their appearance and withdraw from social activities[1][3].
  • Insomnia: Intense itching and discomfort can interfere with sleep, leading to fatigue and difficulty concentrating[1].
  • Social isolation: Visible skin lesions and flaking can make people feel embarrassed or stigmatized, leading them to avoid work, school, or social gatherings[3].
  • Difficulty with intimacy: TSW can affect the genitals and other sensitive areas, causing pain and self-consciousness that can interfere with sexual relationships[1].
  • Frustration and hopelessness: The prolonged and cyclical nature of TSW can leave people feeling discouraged and helpless, especially if they have difficulty finding knowledgeable medical care[3].

These psychological impacts can be just as debilitating as the physical symptoms of TSW. In some cases, they may even lead people to resume using topical steroids in an attempt to find relief, further perpetuating the cycle of addiction and withdrawal.

It’s crucial for people with TSW to have access to mental health support and resources to help cope with the emotional challenges of this condition. Connecting with others who have gone through similar experiences, whether online or in person, can provide valuable validation and encouragement.

Decoding TSW: Insights from Experts and Patients

Despite the significant impact of TSW, this condition remains poorly understood and often misdiagnosed by healthcare providers. Many dermatologists are not aware of the potential for topical steroid addiction and withdrawal, leading to delays in diagnosis and appropriate treatment.

However, there is a growing body of research and clinical experience that is helping to shed light on the causes and management of TSW. One important resource is the blog Decoding Topical Steroid Withdrawal by Jing Rui, a TSW patient and advocate from Singapore[8].

Jing Rui’s blog compiles information from TSW experts like Dr. Marvin Rapaport, Dr. Kenji Sato, and Dr. Mototsugu Fukaya, who have been treating TSW patients for decades. Some key insights from their work include:

  • TSW can occur after as little as 2 weeks of daily topical steroid use, but is more common after 2-4 months of continuous use[4][8].
  • Symptoms tend to be most severe on the face and genital areas where the skin is thinner and more permeable[1][8].
  • Proper diagnosis requires a careful history of topical steroid use and recognition of characteristic signs like the “headlight” pattern of facial redness and “elephant wrinkles” in flexural areas[1][3].
  • Treatment involves complete cessation of topical steroids, gentle skin care, and management of specific symptoms like itch and infection. Phototherapy, traditional Chinese medicine, and specialized serums may also be helpful in some cases[7][8].
  • Moisturizers and other topical products can sometimes worsen TSW symptoms, especially in severe cases, and should be used with caution[7].
  • Stress management is an important part of recovery, but dietary changes alone are unlikely to resolve TSW[7].

By sharing this knowledge in an accessible way, blogs like Decoding Topical Steroid Withdrawal are helping to raise awareness and empower TSW patients to take control of their care. However, much more research is needed to fully understand the mechanisms of TSW and develop evidence-based diagnostic and treatment guidelines.

Preventing and Managing TSW

If you or a loved one are using topical steroids, there are steps you can take to minimize the risk of developing TSW:

  • Use the lowest potency steroid needed to control your symptoms, for the shortest duration possible. Follow your prescriber’s instructions carefully.
  • Do not apply topical steroids more frequently than prescribed, and use only the amount needed to cover the affected area.
  • Avoid applying steroids to the face, genitals, or skin folds unless specifically directed by a dermatologist.
  • Be cautious with “natural” or “herbal” remedies for eczema or psoriasis, as some may contain undisclosed steroids that can lead to TSW[1].
  • Monitor for signs of skin thinning, easy bruising, or stretch marks, which can be early indicators of steroid overuse. If you notice these changes, contact your dermatologist promptly.
  • If you have been using topical steroids for longer than 2-4 weeks, work with your dermatologist on a plan to gradually taper the medication to minimize withdrawal symptoms.

If you suspect that you or a loved one may be experiencing TSW, the first step is to seek evaluation by a knowledgeable dermatologist or other healthcare provider. They can help rule out other conditions that may mimic TSW and develop an appropriate treatment plan.

Management of TSW typically involves:

  • Complete cessation of topical steroid use, either through gradual tapering or “cold turkey” discontinuation depending on the individual case[1].
  • Gentle skin care with fragrance-free, hypoallergenic cleansers and moisturizers to support skin barrier function[1].
  • Medications like oral antihistamines and topical calcineurin inhibitors to manage itch and inflammation[1][2].
  • Antibiotics or antifungals to treat secondary skin infections that can occur due to scratching and skin breakdown[1].
  • Phototherapy with narrowband UVB light to reduce inflammation and promote skin healing in some cases[1].
  • Counseling and stress management techniques to cope with the psychological impacts of TSW[1].

It’s important to remember that recovery from TSW is a highly individual process that can take months to years. Having realistic expectations and a strong support system is crucial for navigating the challenges of withdrawal.

The Road Ahead: Raising Awareness and Advancing Research

While much progress has been made in understanding TSW in recent years, there is still a long way to go in terms of raising awareness and improving diagnosis and treatment of this condition. Many dermatologists remain skeptical about the existence of TSW, and patients often face disbelief or dismissal when seeking care.

Organizations like the National Eczema Association and International Topical Steroid Awareness Network (ITSAN) are working to change this by providing education and support for TSW patients and healthcare providers[2][6]. These groups are also advocating for more research funding and attention to this neglected condition.

Some key priorities for advancing the field of TSW research include:

  • Conducting epidemiological studies to determine the incidence and prevalence of TSW in different populations.
  • Identifying biomarkers or diagnostic criteria that can help distinguish TSW from other skin conditions with similar presentations.
  • Investigating the genetic and environmental factors that may predispose certain individuals to develop TSW.
  • Developing evidence-based guidelines for the prevention, diagnosis, and treatment of TSW that can be widely disseminated to healthcare providers.
  • Exploring the long-term outcomes and comorbidities associated with TSW, including the impact on mental health and quality of life.
  • Evaluating the safety and efficacy of novel therapies for TSW, such as targeted immunomodulators or stem cell treatments.

By collaborating with patient advocates, researchers, and clinicians across disciplines, we can work towards a future where TSW is widely recognized, effectively treated, and ultimately prevented.

Key Points

  • Topical steroid withdrawal (TSW) is a serious condition that can occur from the prolonged, frequent, or inappropriate use of topical corticosteroids, especially high-potency ones.
  • Risk factors for TSW include using topical steroids for longer than 2-4 weeks, applying them more than twice daily, using them on sensitive areas like the face and genitals, and abruptly discontinuing them without tapering.
  • TSW is characterized by severe burning, stinging, and red skin that appears within days to weeks of stopping topical steroids, along with other systemic symptoms like insomnia, fatigue, and depression.
  • The exact prevalence of TSW is unknown, but it is thought to be underdiagnosed due to lack of awareness among healthcare providers.
  • Physiological changes in the skin, such as tachyphylaxis, receptor changes, and barrier dysfunction, contribute to the development of steroid addiction and withdrawal.
  • Psychological factors like anxiety, social isolation, and frustration can exacerbate the impact of TSW on quality of life.
  • Blogs like Decoding Topical Steroid Withdrawal are helping to raise awareness and share expert insights on the diagnosis and management of TSW.
  • Prevention of TSW involves using topical steroids judiciously, following prescriber instructions, and being aware of early signs of overuse.
  • Treatment of TSW typically involves cessation of topical steroids, gentle skin care, medications for itch and inflammation, and psychological support.
  • More research is needed to fully understand the mechanisms, epidemiology, and long-term outcomes of TSW, and to develop evidence-based diagnostic and treatment guidelines.

Frequently Asked Questions

How common is topical steroid withdrawal?

The exact prevalence of TSW is unknown, as it is likely underdiagnosed and underreported. Some estimates suggest that up to 12% of people who use topical steroids for prolonged periods may develop TSW, but more research is needed to confirm these numbers.

Can I use moisturizers or other topical products during TSW?

Moisturizers and emollients can help support skin barrier function and relieve dryness during TSW, but some people find that even gentle products can irritate their skin, especially in severe cases. It’s important to patch test any new products and introduce them slowly, under the guidance of a dermatologist.

Is TSW contagious?

No, TSW is not contagious. It is an individual reaction to the prolonged use of topical corticosteroids and cannot be spread from person to person.

Will my skin ever be the same after TSW?

Most people with TSW do eventually achieve significant improvement in their symptoms, although the timeline can vary widely from months to years. Some may have lingering sensitivity or flares, but these tend to become less frequent and severe over time with proper management and avoidance of triggers.

Are there any support groups for people with TSW?

Yes, there are several online communities and support groups for people with TSW, including the ITSAN forum and various Facebook groups. The National Eczema Association also offers resources and connections for people with eczema and TSW. Joining these groups can provide valuable information, encouragement, and a sense of community during the challenging journey of TSW.

If you or a loved one are struggling with topical steroid withdrawal, know that you are not alone and that help is available. Don’t hesitate to reach out to a dermatologist, mental health professional, or support organization for guidance and care. With time, patience, and the right resources, it is possible to heal from TSW and regain control of your skin health.


  1. Sheary, B. (2018). Topical steroid addiction and withdrawal-An overview for GPs. Australian family physician, 47(10), 668-671.
  2. Hajar, T., Leshem, Y. A., Hanifin, J. M., Nedorost, S. T., Lio, P. A., Paller, A. S., … & Simpson, E. L. (2015). A systematic review of topical corticosteroid withdrawal (“steroid addiction”) in patients with atopic dermatitis and other dermatoses. Journal of the American Academy of Dermatology, 72(3), 541-549.
  3. Juhász, M. L., Curley, R. A., Rasmussen, A., Malakouti, M., Silverberg, N., & Jacob, S. E. (2017). Systematic review of the topical steroid addiction and topical steroid withdrawal phenomenon in children diagnosed with atopic dermatitis and treated with topical corticosteroids. Journal of the Dermatology Nurses’ Association, 9(5), 233-240./li>
  4. Fukaya, M., Sato, K., Sato, M., Kimata, H., Fujisawa, S., Dozono, H., … & Minaguchi, S. (2014). Topical steroid addiction in atopic dermatitis. Drug, healthcare and patient safety, 6, 131.
  5. Sheary, B. (2016). Topical corticosteroid addiction and withdrawal-An overview for GPs. Australian family physician, 45(6), 386-388.
  6. Hengge, U. R., Ruzicka, T., Schwartz, R. A., & Cork, M. J. (2006). Adverse effects of topical glucocorticosteroids. Journal of the American Academy of Dermatology, 54(1), 1-15.
  7. Rui, J. (2020). Decoding Topical Steroid Withdrawal. Retrieved from
  8. Rapaport, M. J., & Rapaport, V. (1999). Prolonged erythema after facial laser resurfacing or phenol peel secondary to corticosteroid addiction. Dermatologic surgery, 25(10), 781-785.
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