Can Exposure to Chickenpox Cause Herpes Flare-Ups? Uncovering Their Clinical Connection

February 28, 2024

Featured image for “Can Exposure to Chickenpox Cause Herpes Flare-Ups? Uncovering Their Clinical Connection”

Chickenpox, shingles, cold sores – what ties these common maladies together? The key lies in the family of herpesviruses that cause them.

Understanding similarities and differences between varicella-zoster virus (VZV) and herpes simplex virus (HSV) provides valuable perspectives on disease potential, testing, prevention, and public health.

This comprehensive guide examines all facets of this complex interplay between chickenpox and herpes. Core areas we’ll explore include:

  • Causative viruses and resulting illnesses
  • Infection patterns and transmission dynamics
  • Diagnostic ambiguities
  • Vaccination and treatment options

Let’s get started!

Causative Viruses Behind Various Conditions

Varicella-Zoster Virus

VZV leads to two clinical entities:


marks primary infection, usually in childhood. Symptoms encompass fever, malaise, and vesicular rash.


results from reactivation of latent VZV residing in dorsal root ganglia after initial chickenpox infection. Painful unilateral rash limited to 1-3 dermatomes is classic.

Herpes Simplex Virus

HSV is further divided into two subtypes:


Traditionally causing orolabial infections like cold sores or fever blisters. But now genital HSV-1 cases are rising.


Predominates in genital herpes, transmitted sexually or at birth. Genital HSV-1 and facial HSV-2 outbreaks also occur.

So while VZV triggers chickenpox and shingles and HSV drives oral and genital herpes, they belong to the same Herpesviridae family. More on their overlap ahead!

Infection Patterns and Transmission Risks

Before examining cross-connections between VZV and HSV, let’s overview their infection kinetics individually:

Varicella-Zoster Virus

  • Respiratory transmission
  • 10-21 days incubation period
  • Lifelong latency after chickenpox
  • Shingles through reactivation in nerves
  • Communicability from vesicles until crusted

Herpes Simplex Virus

  • Skin-to-skin transmission
  • 2 days – 2 weeks incubation
  • Latent in ganglionic neurons
  • Triggers like stress induce recurrence
  • Asymptomatic viral shedding enables transmission

So while modes of spread and domains of latency differ slightly between VZV and HSV, both establish lifelong persistent infection with periodic symptomatic flares. Now onto their potential interplay!

Can Chickenpox Lead to Oral or Genital Herpes?

Chickenpox reflects active systemic VZV infection. But could this viral activity also predispose towards HSV acquisition or activation? Some hypotheses:

Scenario 1

Direct HSV transmission from open chickenpox lesions to unaffected close contacts through physical skin contact.

Scenario 2

VZV replication triggering reactivation of dormant oral or genital HSV due to immunologicoverlap.

While biologically plausible, current evidence has not conclusively documented these phenomena. Further research through coincident sampling of lesions, serology, and molecular tests in patients with concomitant VZV and HSV infections can unlock valuable insights.

For now, assuming associations between chickenpox and subsequent herpes risks appears premature. Moving on to diagnostic challenges when both viruses are possibly at play!

Interpreting Herpes Blood Tests Post-Chickenpox

Could previous chickenpox impact results of serological or PCR tests for herpes? Potentially, yes – due to cross-reactivity between antibodies and antigens shared by this family of viruses.

Scenario 1

Patient with recent chickenpox diagnosed a week back now experiencing first episode of genital lesions.

Positive HSV IgM could signify new HSV infection but could also represent continued circulating VZV antibodies. Concurrent HSV PCR testing would clarify active HSV replication.

Scenario 2

I had childhood chickenpox. After a negative initial oral HSV outbreak test, I still wonder if it could be herpes.

Any positive HSV IgG means previous HSV exposure. But while 90% of adults harbor anti-HSV antibodies, most don’t have clinical oral or genital herpes. So consider repeating PCR or culture tests if symptoms recur.

Therefore, clinicians should thoughtfully interpret positive herpes serology in patients with close-timed VZV diagnoses, corroborating with other diagnostic evidence. Now onto prevention avenues!

Leveraging Vaccines Against These Viruses

Varicella Immunization

The varicella vaccine Varivax prevents over 90% of infections, curbing disease incidence and transmission rates. But breakthrough VZV is possible. Two lifetime doses are recommended for children.

Herpes Simplex Prevention

No vaccines currently exist against HSV. However, modalities like suppressive antiviral therapy, condom usage, and opting monogamy over multiple sexual partners can greatly reduce acquisition risks.

Alongside HPV and hepatitis B vaccination, individuals can protect themselves against various sexually transmitted infections through informed choices.

Combined intelligently, existing options help counter manifold viral threats on both personal and population levels!

Now onto some common chickenpox and herpes queries.

FAQs Covering Chickenpox and Associated Infections

Does overcoming chickenpox also provide immunity against herpes simplex viruses?

No, VZV causing chickenpox is distinct from both HSV-1 and 2. So overcoming varicella does not confer protection against oral or genital herpes from HSV.

Can I undergo herpes blood testing right after recovering from chickenpox?

Due to potential cross-reactivity with VZV, positive IgM HSV tests immediately post-chickenpox could be misleading. Retesting after a few months allows VZV antibodies to normalize while still detecting recent HSV.

Does the varicella vaccine also guard against future cold sores?

No. The varicella vaccine protects against the specific VZV, but not against HSV-1 typically responsible for oral herpes. So while it can prevent chickenpox, getting this vaccine does not stop you from getting cold sores later.

Can someone with oral herpes transmit their infection to kids with chickenpox?

Unlikely. Respiratory spread of VZV causes chickenpox while contact with mucosal secretions transmits HSV. So unless the infected person directly kisses the child’s vesicles, cross-transmission between their infections is improbable.

Is shingles a form of herpes?

Yes. As shingles stems from reactivation of the same VZV latent after chickenpox, it classifies as a disease under the wider umbrella of herpes infections. But while nicknamed “zoster herpes”, it manifests very differently from prototypical oral or genital herpes.

Key Takeaways on Connections Between These Infections

In summary:

  • While distinct viruses, VZV and HSV belong to the Herpesviridae family
  • VZV causes chickenpox and shingles but not typical herpes cases
  • HSV drives oral and genital herpes but not chickenpox or shingles
  • Data linking chickenpox directly with herpes simplex acquisition remains limited
  • Positive post-varicella herpes antibody tests warrants further verification
  • Vaccines exist for VZV but not for HSV as yet

Appreciating their points of convergence and divergence permits better clinical decision-making when evaluating patients possibly co-infected with varicella-zoster and herpes simplex viruses.

Rate this post

Related articles


Cold Plasma System

The world's first handheld cold plasma device

Learn More

Made in USA